Journal
FUTURE MICROBIOLOGY
Volume 8, Issue 2, Pages 147-154Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/FMB.12.140
Keywords
adaptive immunity; Brucella; host-pathogen interaction; innate immunity; zoonosis
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Funding
- Fondation de la Recherche Medicale in France
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The complex immune system of mammals is the result of evolutionary forces that include battles against pathogens, as sensing and defeating intruders is a prerequisite to host survival. On the other hand, microorganisms have evolved multiple mechanisms to evade both arms of immunity: the innate and the adaptive immune systems. The successful pathogenic intracellular bacterium Brucella is not an exception to the rule: Brucella displays mechanisms that allow evasion of immune surveillance in order to establish persistent infections in mammals. In this review, we highlight some key mechanisms that pathogenic Brucella use to evade the adaptive immune system.
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