Journal
FUTURE MICROBIOLOGY
Volume 8, Issue 7, Pages 923-937Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/fmb.13.50
Keywords
antibiotic resistance; Burkholderia; efflux pumps; genomics; new antibiotics; RND
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Funding
- Italian Cystic Fibrosis Research Foundation (FFC) [10]
- Ente Cassa di Risparmio [2008.1103]
- FEMS Advanced Fellowship
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Aim: The aim of this work was to analyze the eight resistance-nodulation-cell division (RND) families (a group of proteins mainly involved in multidrug resistance of Gram-negative bacteria) in 26 Burkholderia genomes in order to gain knowledge regarding their presence and distribution, to obtain a platform for future experimental tests aimed to identify new molecular targets to be used in antimicrobial therapy against Burkholderia species and to refine the annotation of RND-like sequences in these genomes. Materials & methods: A total of 417 coding sequences were retrieved and analyzed using different bioinformatics tools. Results & conclusion: A complex pattern of RND presence and distribution in the different Burkholderia species was disclosed and a core of proteins represented in all 26 genomes was identified. These core' proteins might represent useful targets of new synthetic antimicrobial compounds. Furthermore, the annotation of RND-like sequences in Burkholderia was refined.
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