Journal
FUTURE MICROBIOLOGY
Volume 7, Issue 7, Pages 839-852Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/FMB.12.57
Keywords
environmental pathogen; GASP; intracellular pathogen; PrfA
Categories
Funding
- Public Health Service from NIAID [AI41816, AI083241]
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Environmental pathogens - organisms that survive in the outside environment but maintain the capacity to cause disease in mammals - navigate the challenges of life in habitats that range from water and soil to the cytosol of host cells. The bacterium Listeria monocytogenes has served for decades as a model organism for studies of host-pathogen interactions and for fundamental paradigms of cell biology. This ubiquitous saprophyte has recently become a model for understanding how an environmental bacterium switches to life within human cells. This review describes how L. monocytogenes balances life in disparate environments with the help of a critical virulence regulator known as PrfA. Understanding L. monocytogenes survival strategies is important for gaining insight into how environmental microbes become pathogens.
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