Journal
FUTURE MICROBIOLOGY
Volume 7, Issue 4, Pages 497-512Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/FMB.12.17
Keywords
7,8-dihydro-8-oxoguanine; antioxidant protein; gingipain; oxidative stress; Porphyromonas gingivalis; reactive oxygen species; ROS
Categories
Funding
- Loma Linda University, Schools Medicine and Dentistry
- Public Health Service from NIDCR [DE13664, DE019730]
Ask authors/readers for more resources
Porphyromonas gingivalis, a black-pigmented, Gram-negative anaerobe, is an important etiologic agent of periodontal disease. The harsh inflammatory condition of the periodontal pocket implies that this organism has properties that will facilitate its ability to respond and adapt to oxidative stress. Because the stress response in the pathogen is a major determinant of its virulence, a comprehensive understanding of its oxidative stress resistance strategy is vital. We discuss multiple mechanisms and systems that clearly work in synergy to defend and protect P. gingivalis against oxidative damage caused by reactive oxygen species. The involvement of multiple hypothetical proteins and/or proteins of unknown function in this process may imply other unique mechanisms and potential therapeutic targets.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available