4.3 Review

Road to clinical efficacy: challenges and novel strategies for antimicrobial peptide development

Related references

Note: Only part of the references are listed.
Article Microbiology

Easy Strategy To Protect Antimicrobial Peptides from Fast Degradation in Serum

Daniel Knappe et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2010)

Review Immunology

Cathelicidin LL-37: A Multitask Antimicrobial Peptide

Robert Bucki et al.

ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS (2010)

Article Biochemistry & Molecular Biology

Can antimicrobial peptides scavenge around a cell in less than a second?

Eduard Y. Chekmenev et al.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2010)

Article Biochemistry & Molecular Biology

Divorcing folding from function: How acylation affects the membrane-perturbing properties of an antimicrobial peptide

Brian Vad et al.

BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS (2010)

Article Engineering, Biomedical

Controlling the release of peptide antimicrobial agents from surfaces

Anita Shukla et al.

BIOMATERIALS (2010)

Review Biochemistry & Molecular Biology

Peptoid-Peptide Hybrid Backbone Architectures

Christian A. Olsen

CHEMBIOCHEM (2010)

Article Biochemistry & Molecular Biology

Design and Characterization of an Acid-Activated Antimicrobial Peptide

Lina Li et al.

CHEMICAL BIOLOGY & DRUG DESIGN (2010)

Article Microbiology

Investigation of the Cytotoxicity of Antimicrobial Peptide P40 on Eukaryotic Cells

Rodrigo A. Vaucher et al.

CURRENT MICROBIOLOGY (2010)

Review Biochemistry & Molecular Biology

Antimicrobial peptides from marine invertebrates as a new frontier for microbial infection control

Anselmo Jesus Otero-Gonzalez et al.

FASEB JOURNAL (2010)

Review Microbiology

Defensins as anti-inflammatory compounds and mucosal adjuvants

Karl G. Kohlgraf et al.

FUTURE MICROBIOLOGY (2010)

Article Biochemistry & Molecular Biology

Titanium Immobilized with an Antimicrobial Peptide Derived from Histatin Accelerates the Differentiation of Osteoblastic Cell Line, MC3T3-E1

Seicho Makihira et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2010)

Article Chemistry, Physical

Effect of Hydrophobicity on the Interaction between Antimicrobial Peptides and Poly(acrylic acid) Microgels

Helena Bysell et al.

JOURNAL OF PHYSICAL CHEMISTRY B (2010)

Article Chemistry, Multidisciplinary

Synthesis of the Lantibiotic Lactocin S Using Peptide Cyclizations on Solid Phase

Avena C. Ross et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2010)

Article Biochemistry & Molecular Biology

CAMP: a useful resource for research on antimicrobial peptides

Shaini Thomas et al.

NUCLEIC ACIDS RESEARCH (2010)

Article Multidisciplinary Sciences

Peptidomimetic Antibiotics Target Outer-Membrane Biogenesis in Pseudomonas aeruginosa

Nityakalyani Srinivas et al.

SCIENCE (2010)

Article Multidisciplinary Sciences

Plectasin, a Fungal Defensin, Targets the Bacterial Cell Wall Precursor Lipid II

Tanja Schneider et al.

SCIENCE (2010)

Review Biochemistry & Molecular Biology

Binding of amphipathic α-helical antimicrobial peptides to lipid membranes: Lessons from temporins B and L

Ajay K. Mahalka et al.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2009)

Review Biochemistry & Molecular Biology

Temporins and their synergism against Gram-negative bacteria and in lipopolysaccharide detoxification

Maria Luisa Mangoni et al.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2009)

Review Biochemistry & Molecular Biology

Structure, membrane orientation, mechanism, and function of pexiganan - A highly potent antimicrobial peptide designed from magainin

Lindsey M. Gottler et al.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2009)

Review Biochemistry & Molecular Biology

Antimicrobial peptide mimics for improved therapeutic properties

Shahar Rotem et al.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2009)

Review Biochemistry & Molecular Biology

Control of cell selectivity of antimicrobial peptides

Katsumi Matsuzaki

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2009)

Article Engineering, Biomedical

Incorporation of antimicrobial compounds in mesoporous silica film monolith

Isabel Izquierdo-Barba et al.

BIOMATERIALS (2009)

Review Biochemistry & Molecular Biology

Gramicidin S and polymyxins: the revival of cationic cyclic peptide antibiotics

Tatsushi Mogi et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2009)

Article Biochemistry & Molecular Biology

Dissecting Structural and Functional Diversity of the Lantibiotic Mersacidin

Antony N. Appleyard et al.

CHEMISTRY & BIOLOGY (2009)

Article Hematology

The roles of cathelicidin LL-37 in immune defences and novel clinical applications

Anastasia Nijnik et al.

CURRENT OPINION IN HEMATOLOGY (2009)

Article Pharmacology & Pharmacy

New approaches in peptide antibiotics

Martti Vaara

CURRENT OPINION IN PHARMACOLOGY (2009)

Review Biochemistry & Molecular Biology

Anionic Antimicrobial Peptides from Eukaryotic Organisms

Frederick Harris et al.

CURRENT PROTEIN & PEPTIDE SCIENCE (2009)

Article Chemistry, Medicinal

Preparation and Characterization of Coacervate Microcapsules for the Delivery of Antimicrobial Oyster Peptides

Li Zhang et al.

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY (2009)

Review Biochemistry & Molecular Biology

Multifunctional host defense peptides: intracellular-targeting antimicrobial peptides

Pierre Nicolas

FEBS JOURNAL (2009)

Article Infectious Diseases

Design and activity of a 'dual-targeted' antimicrobial peptide

Jian He et al.

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS (2009)

Article Infectious Diseases

Targeted antimicrobial activity of a specific IgG-SMAP28 conjugate against Porphyromonas gingivalis in a mixed culture

Michael R. Franzman et al.

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS (2009)

Article Infectious Diseases

High in vitro antimicrobial activity of synthetic antimicrobial peptidomimetics against staphylococcal biofilms

Kristina Flemming et al.

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2009)

Review Biotechnology & Applied Microbiology

Dermaseptins and Magainins: Antimicrobial Peptides from Frogs' Skin-New Sources for a Promising Spermicides Microbicides-A Mini Review

Amira Zairi et al.

JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY (2009)

Review Biotechnology & Applied Microbiology

Lantibiotics: Diverse activities and unique modes of action

Sikder M. Asaduzzaman et al.

JOURNAL OF BIOSCIENCE AND BIOENGINEERING (2009)

Article Medicine, Research & Experimental

Molecularly targeted nanocarriers deliver the cytolytic peptide melittin specifically to tumor cells in mice, reducing tumor growth

Neelesh R. Soman et al.

JOURNAL OF CLINICAL INVESTIGATION (2009)

Review Chemistry, Medicinal

Antimicrobial Peptides as Model Molecules for the Development of Novel Antiviral Agents in Aquaculture

A. Falco et al.

MINI-REVIEWS IN MEDICINAL CHEMISTRY (2009)

Article Cell Biology

The effect of C-terminal amidation on the efficacy and selectivity of antimicrobial and anticancer peptides

Sarah Rachel Dennison et al.

MOLECULAR AND CELLULAR BIOCHEMISTRY (2009)

Review Biochemistry & Molecular Biology

Fluorine-a new element in the design of membrane-active peptides

E. Neil G. Marsh et al.

MOLECULAR BIOSYSTEMS (2009)

Article Nanoscience & Nanotechnology

Leishmanicidal Activity and Immobilization of dermaseptin 01 antimicrobial peptides in ultrathin films for nanomedicine applications

Maysa F. Zampa et al.

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2009)

Review Biochemistry & Molecular Biology

The chemistry and biology of LL-37

Matthew F. Burton et al.

NATURAL PRODUCT REPORTS (2009)

Article Nanoscience & Nanotechnology

Self-assembled cationic peptide nanoparticles as an efficient antimicrobial agent

Lihong Liu et al.

NATURE NANOTECHNOLOGY (2009)

Review Microbiology

OPINION Antimicrobial peptides: linking partition, activity and high membrane-bound concentrations

Manuel N. Melo et al.

NATURE REVIEWS MICROBIOLOGY (2009)

Article Biochemistry & Molecular Biology

APD2: the updated antimicrobial peptide database and its application in peptide design

Guangshun Wang et al.

NUCLEIC ACIDS RESEARCH (2009)

Article Chemistry, Multidisciplinary

Targeted Delivery of PSC-RANTES for HIV-1 Prevention using Biodegradable Nanoparticles

Anthony S. Ham et al.

PHARMACEUTICAL RESEARCH (2009)

Article Biochemistry & Molecular Biology

Membrane Permeabilization by Multivalent Anti-Microbial Peptides

Roland J. Pieters et al.

PROTEIN AND PEPTIDE LETTERS (2009)

Article Biochemistry & Molecular Biology

Endotoxin-Neutralizing Peptides as Gram-Negative Sepsis Therapeutics

Kwong-Fai Wong et al.

PROTEIN AND PEPTIDE LETTERS (2009)

Review Dermatology

Bioactive peptides: signaling the future

K. Fields et al.

JOURNAL OF COSMETIC DERMATOLOGY (2009)

Article Engineering, Biomedical

Alternating release of different bioactive molecules from a complexation polymer system

Ju Hyeong Jeon et al.

BIOMATERIALS (2008)

Article Biochemistry & Molecular Biology

Synthetic mimics of antimicrobial peptides

Abhigyan Som et al.

BIOPOLYMERS (2008)

Article Biotechnology & Applied Microbiology

Antibacterial hydrogels of amino acid-based cationic amphiphiles

Sangita Roy et al.

BIOTECHNOLOGY AND BIOENGINEERING (2008)

Review Biochemistry & Molecular Biology

Antimicrobial peptides: natural templates for synthetic membrane-active compounds

A. Giuliani et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2008)

Review Biochemistry & Molecular Biology

The Sushi peptides: structural characterization and mode of action against Gram-negative bacteria

J. L. Ding et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2008)

Article Biochemistry & Molecular Biology

N-Fmoc-protected(α-dipeptidoyl)benzotriazoles for efficient solid-phase peptide synthesis by segment condensation

Alan R. Katritzky et al.

CHEMICAL BIOLOGY & DRUG DESIGN (2008)

Review Infectious Diseases

Are cationic antimicrobial peptides also 'double-edged swords'?

Isaac Ginsburg et al.

EXPERT REVIEW OF ANTI-INFECTIVE THERAPY (2008)

Article Microbiology

RAPD: a database of recombinantly-produced antimicrobial peptides

Yifeng Li et al.

FEMS MICROBIOLOGY LETTERS (2008)

Article Infectious Diseases

Therapeutic challenges in the era of antibiotic resistance

Christopher Lee

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS (2008)

Article Pharmacology & Pharmacy

Antimicrobial effectiveness of liposomal polymyxin B against resistant Gram-negative bacterial strains

Misagh Alipour et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2008)

Article Biochemistry & Molecular Biology

Modification of Antimicrobial Peptide with Low Molar Mass Poly(ethylene glycol)

Genghui Zhang et al.

JOURNAL OF BIOCHEMISTRY (2008)

Article Biochemistry & Molecular Biology

Origin of low mammalian cell toxicity in a class of highly active antimicrobial amphipathic helical peptides

Ayman Hawrani et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2008)

Article Chemistry, Medicinal

Synthetic antimicrobial peptidomimetics with therapeutic potential

Bengt Erik Haug et al.

JOURNAL OF MEDICINAL CHEMISTRY (2008)

Review Critical Care Medicine

Bench-to-bedside review: Clostridium difficile colitis

Carolyn V. Gould et al.

CRITICAL CARE (2008)

Article Biochemistry & Molecular Biology

Stability and activity in sputum of G10KHc, a potent Anti-Pseudomonas antimicrobial peptide

Randal Eckert et al.

CHEMICAL BIOLOGY & DRUG DESIGN (2007)

Article Biochemistry & Molecular Biology

Action mechanism of PEGylated magainin 2 analogue peptide

Yuichi Imura et al.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2007)

Article Pharmacology & Pharmacy

Colonic delivery of compression coated nisin tablets using pectin/HPMC polymer mixture

Timucin Ugurlu et al.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2007)

Review Pharmacology & Pharmacy

Cathelicidins and functional analogues as antisepsis molecules

Neeloffer Mookherjee et al.

EXPERT OPINION ON THERAPEUTIC TARGETS (2007)

Review Pharmacology & Pharmacy

Nanosizing - Oral formulation development and biopharmaceutical evaluation

Filippos Kesisoglou et al.

ADVANCED DRUG DELIVERY REVIEWS (2007)

Article Biochemistry & Molecular Biology

Design and synthesis of cationic Aib-containing antimicrobial peptides: conformational and biological studies

Sofia Zikou et al.

JOURNAL OF PEPTIDE SCIENCE (2007)

Article Chemistry, Medicinal

De novo design of selective antibiotic peptides by incorporation of unnatural amino acids

Rickey P. Hicks et al.

JOURNAL OF MEDICINAL CHEMISTRY (2007)

Article Biochemistry & Molecular Biology

Characterization of the branched antimicrobial peptide M6 by analyzing its mechanism of action and in vivo toxicity

Alessandro Pini et al.

JOURNAL OF PEPTIDE SCIENCE (2007)

Review Infectious Diseases

Pandrug-resistant Gram-negative bacteria: the dawn of the post-antibiotic era?

Matthew E. Falagas et al.

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS (2007)

Review Pharmacology & Pharmacy

Potential therapeutic applications of the cyclotides and related cystine knot mini-proteins

David J. Craik et al.

EXPERT OPINION ON INVESTIGATIONAL DRUGS (2007)

Article Chemistry, Organic

α-peptide/β-peptoid chimeras

Christian A. Olsen et al.

ORGANIC LETTERS (2007)

Article Microbiology

Role of peptide hydrophobicity in the mechanism of action of α-helical antimicrobial peptides

Yuxin Chen et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2007)

Article Microbiology

Novel synthetic antimicrobial peptides against Streptococcus mutans

Jian He et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2007)

Review Infectious Diseases

Daptomycin

David A. Enoch et al.

JOURNAL OF INFECTION (2007)

Review Biotechnology & Applied Microbiology

Antimicrobial and host-defense peptides as new anti-infective therapeutic strategies

Robert E. W. Hancock et al.

NATURE BIOTECHNOLOGY (2006)

Article Microbiology

Targeted killing of Streptococcus mutans by a pheromone-guided smart antimicrobial peptide

Randal Eckert et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2006)

Article Microbiology

Enhancement of antimicrobial activity against Pseudomonas aeruginosa by coadministration of G10KHc and tobramycin

Randal Eckert et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2006)

Article Pharmacology & Pharmacy

Antibacterial peptides for therapeutic use: obstacles and realistic outlook

Alexandra K. Marr et al.

CURRENT OPINION IN PHARMACOLOGY (2006)

Article Biochemistry & Molecular Biology

Rapid solid-phase peptide synthesis using thermal and controlled microwave irradiation

Bernadett Bacsa et al.

JOURNAL OF PEPTIDE SCIENCE (2006)

Review Biochemistry & Molecular Biology

Cell-penetrating peptides and antimicrobial peptides: how different are they?

Sonia Troeira Henriques et al.

BIOCHEMICAL JOURNAL (2006)

Article Biochemistry & Molecular Biology

Design of a peptibody consisting of the antimicrobial peptide dhvar5 and a llama variable heavy-chain antibody fragment

A. Szynol et al.

CHEMICAL BIOLOGY & DRUG DESIGN (2006)

Review Biochemistry & Molecular Biology

The human beta-defensin-3, an antibacterial peptide with multiple biological functions

Vishnu Dhople et al.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2006)

Article Biochemistry & Molecular Biology

Development of HIV fusion inhibitors

SE Schneider et al.

JOURNAL OF PEPTIDE SCIENCE (2005)

Article Chemistry, Analytical

Antimicrobial peptides for detection of bacteria in biosensor assays

NV Kulagina et al.

ANALYTICAL CHEMISTRY (2005)

Article Chemistry, Multidisciplinary

Chewing gum of antimicrobial decapeptide (KSL) as a sustained antiplaque agent: Preformulation study

DH Na et al.

JOURNAL OF CONTROLLED RELEASE (2005)

Article Microbiology

Antimicrobial peptide therapeutics for cystic fibrosis

LJ Zhang et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2005)

Review Dermatology

The role of toll-like receptors in the pathogenesis and treatment of dermatological disease

JE McInturff et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2005)

Letter Infectious Diseases

Clinical development of antimicrobial peptides

E Andrès et al.

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS (2005)

Review Biochemical Research Methods

Defensins and other antimicrobial peptides: A historical perspective and an update

T Ganz

COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING (2005)

Review Microbiology

Antimicrobial peptides: Pore formers or metabolic inhibitors in bacteria?

KA Brogden

NATURE REVIEWS MICROBIOLOGY (2005)

Review Biochemistry & Molecular Biology

Natural products to drugs: daptomycin and related lipopeptide antibiotics

RH Baltz et al.

NATURAL PRODUCT REPORTS (2005)

Article Microbiology

De Novo design of potent antimicrobial peptides

V Frecer et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2004)

Review Infectious Diseases

Antimicrobial peptides: premises and promises

KVR Reddy et al.

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS (2004)

Review Biochemistry & Molecular Biology

θ-defensins:: Cyclic antimicrobial peptides produced by binary ligation of truncated α-defensins

ME Selsted

CURRENT PROTEIN & PEPTIDE SCIENCE (2004)

Article Biotechnology & Applied Microbiology

Encapsulation of nisin and lysozyme in liposomes enhances efficacy against Listeria monocytogenes

LM Were et al.

JOURNAL OF FOOD PROTECTION (2004)

Review Biochemistry & Molecular Biology

The world of beta- and gamma-peptides comprised of homologated proteinogenic amino acids and other components

D Seebach et al.

CHEMISTRY & BIODIVERSITY (2004)

Article Microbiology

Novispirin G10-induced lung toxicity in a Klebsiella pneumoniae infection model

KH Bartlett et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2003)

Article Chemistry, Multidisciplinary

Molecular targeting of drug delivery systems to ovarian cancer by BH3 and LHRH peptides

SS Dharap et al.

JOURNAL OF CONTROLLED RELEASE (2003)

Article Biotechnology & Applied Microbiology

Large-scale manufacture of peptide therapeutics by chemical synthesis

BL Bray

NATURE REVIEWS DRUG DISCOVERY (2003)

Review Urology & Nephrology

What are renal defensins defending?

KL Donovan et al.

NEPHRON EXPERIMENTAL NEPHROLOGY (2003)

Article Chemistry, Applied

Rapid, continuous solution-phase peptide synthesis: Application to peptides of pharmaceutical interest

LA Carpino et al.

ORGANIC PROCESS RESEARCH & DEVELOPMENT (2003)

Article Dentistry, Oral Surgery & Medicine

Safety and clinical effects of topical histatin gels in humans with experimental gingivitis

DW Paquette et al.

JOURNAL OF CLINICAL PERIODONTOLOGY (2002)

Article Chemistry, Multidisciplinary

Solid-phase synthesis of fullerene-peptides

D Pantarotto et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2002)

Article Biochemistry & Molecular Biology

Cloaking cytolytic peptides for liposome-based detection and potential drug delivery

HS Aojula et al.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2002)

Article Biochemistry & Molecular Biology

Clavanin permeabilizes target membranes via two distinctly different pH-dependent mechanisms

EJM van Kan et al.

BIOCHEMISTRY (2002)

Review Biochemistry & Molecular Biology

β-amino acids:: Versatile peptidomimetics

DL Steer et al.

CURRENT MEDICINAL CHEMISTRY (2002)

Article Biochemistry & Molecular Biology

Antimicrobial dendrimeric peptides

JP Tam et al.

EUROPEAN JOURNAL OF BIOCHEMISTRY (2002)

Review Multidisciplinary Sciences

Antimicrobial peptides of multicellular organisms

M Zasloff

NATURE (2002)

Article Biochemistry & Molecular Biology

Recognition of lipopeptides by Toll-like receptors

K Takeda et al.

JOURNAL OF ENDOTOXIN RESEARCH (2002)

Article Chemistry, Medicinal

In vitro aerosol delivery and regional airway surface liquid concentration of a liposomal cationic peptide

CF Lange et al.

JOURNAL OF PHARMACEUTICAL SCIENCES (2001)

Review Immunology

Innate immunity and the normal microflora

HG Boman

IMMUNOLOGICAL REVIEWS (2000)