Journal
FUTURE MICROBIOLOGY
Volume 6, Issue 12, Pages 1475-1484Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/FMB.11.131
Keywords
adhesion; autophagy; drug resistance; fungal infections; phagocytosis; stress response
Categories
Funding
- AMS
- Austrian Science Fund [FWF B12-19966, B20-23355]
- Herzfelder Foundation
- Austrian Science Fund (FWF) [P 23355] Funding Source: researchfish
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Candida glabrata is closely related to yeast but obviously adapted to human commensalism. Communication with the environment is important to adjust allocation of resources between protection and proliferation in order to adapt to different situations in and outside of the host. Gene transcription regulated by environmental conditions is a major response strategy of simple fungal organisms. Differences to yeast include an extended repertoire of adhesive genes, and high drug, starvation and stress resistance. These properties largely do not originate from novel virulence genes but rather from adaptations of the transcriptional wiring. C. glabrata signaling pathways providing stress protection are adopted to meet conditions possibly encountered in a host-pathogen confrontation. The view on C. glabrata is getting clearer and points to a simple strategy combining resilience and a few adaptations.
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