Journal
FUTURE MICROBIOLOGY
Volume 5, Issue 2, Pages 303-311Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/FMB.09.121
Keywords
flavivirus; HIV; influenza; screen; siRNA; viral host factor; virus
Categories
Funding
- National Institute of Allergy and Infectious Diseases
- National Institutes of Health
- Department of Health and Human Services
- Emerging Infectious Disease Research [AI081680]
Ask authors/readers for more resources
The recent development of RNAi-based techniques for protein knockdown in mammalian cells has allowed for unprecedented flexibility in the study of protein function. Currently, large siRNA libraries are available that allow the knockdown of all proteins known to be encoded by the human genome. These libraries have been used to identify the host proteins required for the replication of several clinically important viruses, including HIV, flaviviruses and influenza. This review summarizes the methods used in RNAi-based screening for host factors involved in virus replication, and discusses published examples of such screens.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available