Journal
FUTURE MICROBIOLOGY
Volume 4, Issue 4, Pages 401-412Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/FMB.09.10
Keywords
bacteria; Campylobacter jejuni; glycoengineering; glycosylation; PglB; vaccine
Categories
Funding
- BBSRC
- Gates Foundation
- BBSRC [BB/F009321/1] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/F009321/1] Funding Source: researchfish
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Traditionally, glycoproteins have been considered the exclusive property of eukaryotes and archaea, but it is now evident that glycoproteins are found in all domains of life. In recent years Winked glycosylation among some epsilon-proteobacteria has emerged as a new and exciting research area and represents a useful model to understand this complex process in simple, genetically tractable bacteria. Above all, the transfer of Winked glycosylation systems to the work-horse bacterium, Escherichia coli, has enabled, for the first time, the production of recombinant glycoproteins. This has potentially provided the option for tailor-made glycoproteins and has opened up the field of glycoengineering, particularly with respect to the development of glycoconjugate vaccines.
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