Journal
FUTURE MICROBIOLOGY
Volume 4, Issue 10, Pages 1353-1362Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/FMB.09.98
Keywords
apoptosis; cAMP signaling; DPP3; farnesol-mediated cell death; interspecies communication; lipid signaling; lipid sinks; necrosis; NRG1; Ras1; TUP1; white and opaque cells
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Funding
- Constance Miriam and Ethel Corrine Syford Memorial Fund
- Hammond-Maude Fling Fellowship
- Farnesol and Candida albicans Research Fund
- University of Nebraska Foundation
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Farnesol is a quorum-sensing molecule produced by Candida albicans that has many effects, including filament inhibition of this polymorphic fungus. In the past 9 years, the effect of farnesol on C, albicans has been reported in nearly 160 publications, with early work examining its influence on morphology. This article presents an update on the literature published since 2006, focusing on points that still need to be resolved as well as identifying possible artifacts that might interfere with this goal. In addition, the regulation of C. albicans farnesol production, C, albicans' resistance/sensitivity to farnesol and the influence of farnesol on other species as well as the host are discussed, It is intriguing that we still do not know precisely how farnesol works, but interference with the Ras1-cAMP pathway is part of the story.
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