Related references
Note: Only part of the references are listed.ASD v2.0: updated content and novel features focusing on allosteric regulation
Zhimin Huang et al.
NUCLEIC ACIDS RESEARCH (2014)
Strategies for the Selective Regulation of Kinases with Allosteric Modulators: Exploiting Exclusive Structural Features
Zhizhou Fang et al.
ACS CHEMICAL BIOLOGY (2013)
New insights into the structure and function of the pseudokinase domain in JAK2
Olli Silvennoinen et al.
BIOCHEMICAL SOCIETY TRANSACTIONS (2013)
Allosite: a method for predicting allosteric sites
Wenkang Huang et al.
BIOINFORMATICS (2013)
Optimization of allosteric MEK inhibitors. Part 1: Venturing into underexplored SAR territories
Ingo V. Hartung et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2013)
Structure-based discovery of cellular-active allosteric inhibitors of FAK
Naoki Tomita et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2013)
COP1 targets C/EBPα for degradation and induces acute myeloid leukemia via Trib1
Akihiro Yoshida et al.
BLOOD (2013)
Oncogenic ERBB3 Mutations in Human Cancers
Bijay S. Jaiswal et al.
CANCER CELL (2013)
Developing Irreversible Inhibitors of the Protein Kinase Cysteinome
Qingsong Liu et al.
CHEMISTRY & BIOLOGY (2013)
Selective Bisubstrate Inhibitors with Sub-nanomolar Affinity for Protein Kinase Pim-1
Ramesh Ekambaram et al.
CHEMMEDCHEM (2013)
Discovery and characterization of novel allosteric FAK inhibitors
Misa Iwatani et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2013)
Small interfering RNA targeting ILK inhibits metastasis in human tongue cancer cells through repression of epithelial-to-mesenchymal transition
Yu Xing et al.
EXPERIMENTAL CELL RESEARCH (2013)
Overexpression of integrin-linked kinase (ILK) is associated with tumor progression and an unfavorable prognosis in patients with colorectal cancer
Rui Li et al.
JOURNAL OF MOLECULAR HISTOLOGY (2013)
Critical role of Trib1 in differentiation of tissue-resident M2-like macrophages
Takashi Satoh et al.
NATURE (2013)
Mechanism of MEK inhibition determines efficacy in mutant KRAS- versus BRAF-driven cancers
Georgia Hatzivassiliou et al.
NATURE (2013)
Chaperones as thermodynamic sensors of drug-target interactions reveal kinase inhibitor specificities in living cells
Mikko Taipale et al.
NATURE BIOTECHNOLOGY (2013)
An integrin-ILK-microtubule network orients cell polarity and lumen formation in glandular epithelium
Nasreen Akhtar et al.
NATURE CELL BIOLOGY (2013)
Natural-product-derived fragments for fragment-based ligand discovery
Bjoern Over et al.
NATURE CHEMISTRY (2013)
Structure of a pseudokinase-domain switch that controls oncogenic activation of Jak kinases
Angela V. Toms et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2013)
Structure-kinetic relationship study of CDK8/CycC specific compounds
Elisabeth V. Schneider et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
Structural Basis of RIP1 Inhibition by Necrostatins
Tian Xie et al.
STRUCTURE (2013)
ILK and PRDX1 are prognostic markers in squamous cell/adenosquamous carcinomas and adenocarcinoma of gallbladder
Jinghe Li et al.
TUMOR BIOLOGY (2013)
Topical Antiangiogenic SRPK1 Inhibitors Reduce Choroidal Neovascularization in Rodent Models of Exudative AMD
Melissa V. Gammons et al.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2013)
Targeting Diverse Signaling Interaction Sites Allows the Rapid Generation of Bivalent Kinase Inhibitors
Zachary B. Hill et al.
ACS CHEMICAL BIOLOGY (2012)
Clinical and radiological features of Japanese patients with a severe phenotype due to CASK mutations
Jun-ichi Takanashi et al.
AMERICAN JOURNAL OF MEDICAL GENETICS PART A (2012)
Targeting ILK and β4 integrin abrogates the invasive potential of ovarian cancer
Yoon Pyo Choi et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2012)
Identification of novel series of pyrazole and indole-urea based DFG-out PYK2 inhibitors
Samit K. Bhattacharya et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2012)
Identification of TRIB1 R107L gain-of-function mutation in human acute megakaryocytic leukemia
Takashi Yokoyama et al.
BLOOD (2012)
Exploiting protein flexibility to predict the location of allosteric sites
Alejandro Panjkovich et al.
BMC BIOINFORMATICS (2012)
A guide to picking the most selective kinase inhibitor tool compounds for pharmacological validation of drug targets
Joost C. M. Uitdehaag et al.
BRITISH JOURNAL OF PHARMACOLOGY (2012)
A Novel Approach to the Discovery of Small-Molecule Ligands of CDK2
Mathew P. Martin et al.
CHEMBIOCHEM (2012)
Substrate-Selective Inhibition of Protein Kinase PDK1 by Small Compounds that Bind to the PIF-Pocket Allosteric Docking Site
Katrien Busschots et al.
CHEMISTRY & BIOLOGY (2012)
RAS/RAF/MEK Inhibitors in Oncology
M. Broggini
CURRENT MEDICINAL CHEMISTRY (2012)
Fragment Based Drug Design: From Experimental to Computational Approaches
A. Kumar et al.
CURRENT MEDICINAL CHEMISTRY (2012)
ILK: a pseudokinase in the center stage of cell-matrix adhesion and signaling
Jun Qin et al.
CURRENT OPINION IN CELL BIOLOGY (2012)
FOG-1 and GATA-1 act sequentially to specify definitive megakaryocytic and erythroid progenitors
Elena Mancini et al.
EMBO JOURNAL (2012)
CASK aberrations in male patients with Ohtahara syndrome and cerebellar hypoplasia
Hirotomo Saitsu et al.
EPILEPSIA (2012)
Exploiting the anti-inflammatory effects of AMP-activated protein kinase activation
Ian P. Salt et al.
EXPERT OPINION ON INVESTIGATIONAL DRUGS (2012)
Direct AMP-activated protein kinase activators: a review of evidence from the patent literature
Fabrizio Giordanetto et al.
EXPERT OPINION ON THERAPEUTIC PATENTS (2012)
Discovery and Optimization of a Series of 3-(3-Phenyl-3H-imidazo[4,5-b]pyridin-2-yl)pyridin-2-amines: Orally Bioavailable, Selective, and Potent ATP-Independent Akt Inhibitors
Mark A. Ashwell et al.
JOURNAL OF MEDICINAL CHEMISTRY (2012)
2-(3-Oxo-1,3-diphenylpropyl)malonic Acids as Potent Allosteric Ligands of the PIF Pocket of Phosphoinositide-Dependent Kinase-1: Development and Prodrug Concept
Adriana Wilhehm et al.
JOURNAL OF MEDICINAL CHEMISTRY (2012)
Discovery of Novel Allosteric Mitogen-Activated Protein Kinase Kinase (MEK) 1,2 Inhibitors Possessing Bidentate Ser212 Interactions
Robert A. Heald et al.
JOURNAL OF MEDICINAL CHEMISTRY (2012)
Lipid Molecules Induce p38α Activation via a Novel Molecular Switch
Netanel Tzarum et al.
JOURNAL OF MOLECULAR BIOLOGY (2012)
Engineering human MEK-1 for structural studies: A case study of combinatorial domain hunting
Christoph Meier et al.
JOURNAL OF STRUCTURAL BIOLOGY (2012)
Direct Binding Assay for the Detection of Type IV Allosteric Inhibitors of Abl
Ralf Schneider et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2012)
Crystal structures of the JAK2 pseudokinase domain and the pathogenic mutant V617F
Rajintha M. Bandaranayake et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2012)
A Novel Protein Kinase-Like Domain in a Selenoprotein, Widespread in the Tree of Life
Malgorzata Dudkiewicz et al.
PLOS ONE (2012)
Fluorophore Labeled Kinase Detects Ligands That Bind within the MAPK Insert of p38α Kinase
Matthaeus Getlik et al.
PLOS ONE (2012)
The Raine Syndrome Protein FAM20C Is a Golgi Kinase That Phosphorylates Bio-Mineralization Proteins
Hiroyuki O. Ishikawa et al.
PLOS ONE (2012)
Roco kinase structures give insights into the mechanism of Parkinson disease-related leucine-rich-repeat kinase 2 mutations
Bernd K. Gilsbach et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
Secreted Kinase Phosphorylates Extracellular Proteins That Regulate Biomineralization
Vincent S. Tagliabracci et al.
SCIENCE (2012)
A Back-to-Front Fragment-Based Drug Design Search Strategy Targeting the DFG-Out Pocket of Protein Tyrosine Kinases
Hidehisa Iwata et al.
ACS MEDICINAL CHEMISTRY LETTERS (2012)
Novel Carboxamide-Based Allosteric MEK Inhibitors: Discovery and Optimization Efforts toward XL518 (GDC-0973)
Kenneth D. Rice et al.
ACS MEDICINAL CHEMISTRY LETTERS (2012)
MLR-1023 Is a Potent and Selective Allosteric Activator of Lyn Kinase In Vitro That Improves Glucose Tolerance In Vivo
Michael S. Saporito et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2012)
Biosensor-Based Approach to the Identification of Protein Kinase Ligands with Dual-Site Modes of Action
Iva Navratilova et al.
JOURNAL OF BIOMOLECULAR SCREENING (2012)
Discovery and Characterization of Non-ATP Site Inhibitors of the Mitogen Activated Protein (MAP) Kinases
Kenneth M. Comess et al.
ACS CHEMICAL BIOLOGY (2011)
Discovery of a Potential Allosteric Ligand Binding Site in CDK2
Stephane Betzi et al.
ACS CHEMICAL BIOLOGY (2011)
Discovery of a novel class of non-ATP site DFG-out state p38 inhibitors utilizing computationally assisted virtual fragment-based drug design (vFBDD)
Kristofer Moffett et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2011)
Discovery of TAK-733, a potent and selective MEK allosteric site inhibitor for the treatment of cancer
Qing Dong et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2011)
Design and synthesis of novel allosteric MEK inhibitor CH4987655 as an orally available anticancer agent
Yoshiaki Isshiki et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2011)
Conformational Control Inhibition of the BCR-ABL1 Tyrosine Kinase, Including the Gatekeeper T315I Mutant, by the Switch-Control Inhibitor DCC-2036
Wayne W. Chan et al.
CANCER CELL (2011)
The secret life of kinases: functions beyond catalysis
Jens Rauch et al.
CELL COMMUNICATION AND SIGNALING (2011)
Allosteric Regulation of Protein Kinase PKCζ by the N-Terminal C1 Domain and Small Compounds to the PIF-Pocket
Laura A. Lopez-Garcia et al.
CHEMISTRY & BIOLOGY (2011)
Discovery and Characterization of a Cell-Permeable, Small-Molecule c-Abl Kinase Activator that Binds to the Myristoyl Binding Site
Jingsong Yang et al.
CHEMISTRY & BIOLOGY (2011)
Specific CLK Inhibitors from a Novel Chemotype for Regulation of Alternative Splicing
Oleg Fedorov et al.
CHEMISTRY & BIOLOGY (2011)
Targeting Energy Metabolic and Oncogenic Signaling Pathways in Triple-negative Breast Cancer by a Novel Adenosine Monophosphate-activated Protein Kinase (AMPK) Activator
Kuen-Haur Lee et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
First-in-Man Clinical Trial of the Oral Pan-AKT Inhibitor MK-2206 in Patients With Advanced Solid Tumors
Timothy A. Yap et al.
JOURNAL OF CLINICAL ONCOLOGY (2011)
Phenotypic spectrum associated with CASK loss-of-function mutations
Ute Moog et al.
JOURNAL OF MEDICAL GENETICS (2011)
4-Benzimidazolyl-3-Phenylbutanoic Acids As Novel Pif-Pocket-Targeting Allosteric Inhibitors of Protein Kinase PKCζ
Wolfgang Froehner et al.
JOURNAL OF MEDICINAL CHEMISTRY (2011)
Crystal Structures of ABL-Related Gene (ABL2) in Complex with Imatinib, Tozasertib (VX-680), and a Type I Inhibitor of the Triazole Carbothioamide Class
Eidarus Salah et al.
JOURNAL OF MEDICINAL CHEMISTRY (2011)
Exploring the Binding Sites of Glycogen Synthase Kinase 3. Identification and Characterization of Allosteric Modulation Cavities
Valle Palomo et al.
JOURNAL OF MEDICINAL CHEMISTRY (2011)
Leucettines, a Class of Potent Inhibitors of cdc2-Like Kinases and Dual Specificity, Tyrosine Phosphorylation Regulated Kinases Derived from the Marine Sponge Leucettamine B: Modulation of Alternative Pre-RNA Splicing
Mansour Debdab et al.
JOURNAL OF MEDICINAL CHEMISTRY (2011)
How Does a Drug Molecule Find Its Target Binding Site?
Yibing Shan et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2011)
Too many roads not taken
Aled M. Edwards et al.
NATURE (2011)
Comprehensive analysis of kinase inhibitor selectivity
Mindy I. Davis et al.
NATURE BIOTECHNOLOGY (2011)
Drug discovery and the human kinome: Recent trends
Richard Eglen et al.
PHARMACOLOGY & THERAPEUTICS (2011)
Turning a protein kinase on or off from a single allosteric site via disulfide trapping
Jack D. Sadowsky et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
Structural analysis of an MK2-inhibitor complex: insight into the regulation of the secondary structure of the Gly-rich loop by TEI-I01800
Aiko Fujino et al.
ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY (2010)
Insights into protein kinase regulation and inhibition by large scale structural comparison
Jeyanthy Eswaran et al.
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS (2010)
Design and synthesis of benzoazepin-2-one analogs as allosteric binders targeting the PIF pocket of PDK1
Linyi Wei et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2010)
Switch control pocket inhibitors of p38-MAP kinase. Durable type II inhibitors that do not require binding into the canonical ATP hinge region
Yu Mi Ahn et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2010)
Structure-based design and synthesis of pyrrole derivatives as MEK inhibitors
Michael B. Wallace et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2010)
Trib1 links the MEK1/ERK pathway in myeloid leukemogenesis
Takashi Yokoyama et al.
BLOOD (2010)
Differential ability of Tribbles family members to promote degradation of C/EBPα and induce acute myelogenous leukemia
Priya H. Dedhia et al.
BLOOD (2010)
Transformation by Tribbles homolog 2 (Trib2) requires both the Trib2 kinase domain and COP1 binding
Karen Keeshan et al.
BLOOD (2010)
Bisubstrate Inhibitors of Protein Kinases: from Principle to Practical Applications
Darja Lavogina et al.
CHEMMEDCHEM (2010)
Pseudokinases-remnants of evolution or key allosteric regulators?
Elton Zeqiraj et al.
CURRENT OPINION IN STRUCTURAL BIOLOGY (2010)
Akt inhibitors in clinical development for the treatment of cancer
Sumanta Kumar Pal et al.
EXPERT OPINION ON INVESTIGATIONAL DRUGS (2010)
Discovery of PDK1 Kinase Inhibitors with a Novel Mechanism of Action by Ultrahigh Throughput Screening
Ekaterina V. Bobkova et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Small molecule BDNF mimetics activate TrkB signaling and prevent neuronal degeneration in rodents
Stephen M. Massa et al.
JOURNAL OF CLINICAL INVESTIGATION (2010)
Displacement Assay for the Detection of Stabilizers of Inactive Kinase Conformations
Sabine Klueter et al.
JOURNAL OF MEDICINAL CHEMISTRY (2010)
Through the Gatekeeper Door: Exploiting the Active Kinase Conformation
Fabio Zuccotto et al.
JOURNAL OF MEDICINAL CHEMISTRY (2010)
Binding or Bending: Distinction of Allosteric Abl Kinase Agonists from Antagonists by an NMR-Based Conformational Assay
Wolfgang Jahnke et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2010)
Targeting Bcr-Abl by combining allosteric with ATP-binding-site inhibitors
Jianming Zhang et al.
NATURE (2010)
The (un)targeted cancer kinome
Oleg Fedorov et al.
NATURE CHEMICAL BIOLOGY (2010)
JAK2 V617F Constitutive Activation Requires JH2 Residue F595: A Pseudokinase Domain Target for Specific Inhibitors
Alexandra Dusa et al.
PLOS ONE (2010)
Crystal Structure of Human AKT1 with an Allosteric Inhibitor Reveals a New Mode of Kinase Inhibition
Wen-I Wu et al.
PLOS ONE (2010)
ErbB3/HER3 intracellular domain is competent to bind ATP and catalyze autophosphorylation
Fumin Shi et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Allosteric IGF-1R Inhibitors
Timo Heinrich et al.
ACS MEDICINAL CHEMISTRY LETTERS (2010)
A Missense Mutation in CASK Causes FG Syndrome in an Italian Family
Giulio Piluso et al.
AMERICAN JOURNAL OF HUMAN GENETICS (2009)
FAM20B is a kinase that phosphorylates xylose in the glycosaminoglycan-protein linkage region
Toshiyasu Koike et al.
BIOCHEMICAL JOURNAL (2009)
Characterization of the CHK1 Allosteric Inhibitor Binding Site
Darin Vanderpool et al.
BIOCHEMISTRY (2009)
Kinetic Mechanism and Inhibitor Characterization of WNK1 Kinase
Yukiko I. Yagi et al.
BIOCHEMISTRY (2009)
Crystal Structures of MEK1 Binary and Ternary Complexes with Nucleotides and Inhibitors
Thierry O. Fischmann et al.
BIOCHEMISTRY (2009)
Development of thioquinazolinones, allosteric Chk1 kinase inhibitors
Antonella Converso et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2009)
Allosteric inhibitors of Akt1 and Akt2: Discovery of [1,2,4]triazolo[3,4-f][1,6]naphthyridines with potent and balanced activity
Yiwei Li et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2009)
RDEA119/BAY 869766: A Potent, Selective, Allosteric Inhibitor of MEK1/2 for the Treatment of Cancer
Cory Iverson et al.
CANCER RESEARCH (2009)
Large-Scale Structural Analysis of the Classical Human Protein Tyrosine Phosphatome
Alastair J. Barr et al.
CELL (2009)
The Design, Synthesis and Potential Utility of Fluorescence Probes that Target DFG-out Conformation of p38α for High Throughput Screening Binding Assay
Haile Tecle et al.
CHEMICAL BIOLOGY & DRUG DESIGN (2009)
Identification of Allosteric PIF-Pocket Ligands for PDK1 using NMR-Based Fragment Screening and 1H-15N TROSY Experiments
Brian J. Stockman et al.
CHEMICAL BIOLOGY & DRUG DESIGN (2009)
Activated Abl kinase inhibits oncogenic transforming growth factor-β signaling and tumorigenesis in mammary tumors
Tressa M. Allington et al.
FASEB JOURNAL (2009)
p38α MAP Kinase C-Terminal Domain Binding Pocket Characterized by Crystallographic and Computational Analyses
J. Jefferson P. Perry et al.
JOURNAL OF MOLECULAR BIOLOGY (2009)
An allosteric kinase inhibitor binds the p21-activated kinase autoregulatory domain covalently
Julien Viaud et al.
MOLECULAR CANCER THERAPEUTICS (2009)
The Pseudoactive Site of ILK Is Essential for Its Binding to α-Parvin and Localization to Focal Adhesions
Koichi Fukuda et al.
MOLECULAR CELL (2009)
A new screening assay for allosteric inhibitors of cSrc
Jeffrey R. Simard et al.
NATURE CHEMICAL BIOLOGY (2009)
Structure and allosteric effects of low-molecular-weight activators on the protein kinase PDK1
Valerie Hindie et al.
NATURE CHEMICAL BIOLOGY (2009)
A systematic, large-scale resequencing screen of X-chromosome coding exons in mental retardation
Patrick S. Tarpey et al.
NATURE GENETICS (2009)
Structural analysis of the catalytically inactive kinase domain of the human EGF receptor 3
Natalia Jura et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Structure of the Pseudokinase VRK3 Reveals a Degraded Catalytic Site, a Highly Conserved Kinase Fold, and a Putative Regulatory Binding Site
Eric D. Scheeff et al.
STRUCTURE (2009)
2-Alkylamino- and alkoxy-substituted 2-amino-1,3,4-oxadiazoles-O-Alkyl benzohydroxamate esters replacements retain the desired inhibition and selectivity against MEK (MAP ERK kinase)
Joseph S. Warmus et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2008)
Development of potent, allosteric dual Akt1 and Akt2 inhibitors with improved physical properties and cell activity
Zhijian Zhao et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2008)
CASK functions as a Mg2+-independent neurexin kinase
Konark Mukherjee et al.
CELL (2008)
An isoform-selective, small-molecule inhibitor targets the autoregulatory mechanism of p21-activated kinase
Sean W. Deacon et al.
CHEMISTRY & BIOLOGY (2008)
Integrin-linked kinase - essential roles in physiology and cancer biology
Paul C. McDonald et al.
JOURNAL OF CELL SCIENCE (2008)
Development of paramagnetic probes for molecular recognition studies in protein kinases
Jesus Vazquez et al.
JOURNAL OF MEDICINAL CHEMISTRY (2008)
Identification of a new JNK inhibitor targeting the JNK-JIP interaction site
John L. Stebbins et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Four-jointed is a Golgi kinase that phosphorylates a subset of cadherin domains
Hiroyuki O. Ishikawa et al.
SCIENCE (2008)
Exploring chemical space with organometallics: Ruthenium complexes as protein kinase inhibitors
Eric Meggers et al.
SYNLETT (2007)
Mutagenesis of p38α MAP kinase establishes key roles of Phe169 in function and structural dynamics and reveals a novel DFG-OUT state
Marina Bukhtiyarova et al.
BIOCHEMISTRY (2007)
Structure-based design, synthesis, and biological evaluation of potent and selective macrocyclic checkpoint kinase 1 inhibitors
Zhi-Fu Tao et al.
JOURNAL OF MEDICINAL CHEMISTRY (2007)
Characterization of ATP-independent ERK inhibitors identified through in silico analysis of the active ERK2 structure
Fengming Chen et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2006)
Allosteric activation of the protein kinase PDK1 with low molecular weight compounds
Matthias Engel et al.
EMBO JOURNAL (2006)
Discovery and development of sorafenib: a multikinase inhibitor for treating cancer
Scott Wilhelm et al.
NATURE REVIEWS DRUG DISCOVERY (2006)
Allosteric inhibitors of Bcr-abl-dependent cell proliferation
FJ Adrián et al.
NATURE CHEMICAL BIOLOGY (2006)
Emerging roles of pseudokinases
Jerome Boudeau et al.
TRENDS IN CELL BIOLOGY (2006)
Strategies for the NMR-based identification and optimization of allosteric protein kinase inhibitors
W Jahnke et al.
CHEMBIOCHEM (2005)
Screening of protein kinases by ATP-STD NMR spectroscopy
MA McCoy et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2005)
The crystal structure of a c-Src complex in an active conformation suggests possible steps in c-Src activation
SW Cowan-Jacob et al.
STRUCTURE (2005)
c-Abl tyrosine kinase regulates caspase-9 autocleavage in the apoptotic response to DNA damage
D Raina et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Characterization of AMN107, a selective inhibitor of native and mutant Bcr-Abl
E Weisberg et al.
CANCER CELL (2005)
Allosteric Akt (PKB) inhibitors: discovery and SAR of isozyme selective inhibitors
CW Lindsley et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2005)
Identification of novel p38α MAP kinase inhibitors using fragment-based lead generation
AL Gill et al.
JOURNAL OF MEDICINAL CHEMISTRY (2005)
A unique structure for epidermal growth factor receptor bound to GW572016 (Lapatinib): Relationships among protein conformation, inhibitor off-rate, and receptor activity in tumor cells
ER Wood et al.
CANCER RESEARCH (2004)
Structures of human MAP kinase kinase 1 (MEK1) and MEK2 describe novel noncompetitive kinase inhibition
JF Ohren et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2004)
Crystal structure of the kinase domain of WNK1, a kinase that causes a hereditary form of hypertension
XS Min et al.
STRUCTURE (2004)
Searching for new allosteric sites in enzymes
JA Hardy et al.
CURRENT OPINION IN STRUCTURAL BIOLOGY (2004)
Structural and biochemical evidence for an autoinhibitory role for tyrosine 984 in the juxtamembrane region of the insulin receptor
SQ Li et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
SKIP3, a novel Drosophila tribbles ortholog, is overexpressed in human tumors and is regulated by hypoxia
AJ Bowers et al.
ONCOGENE (2003)
Structural basis for the autoinhibition of c-Abl tyrosine kinase
B Nagar et al.
CELL (2003)
Physiological concentrations of divalent magnesium ion activate the serine/threonine specific protein kinase ERK2
WF Waas et al.
BIOCHEMISTRY (2003)
The protein kinase complement of the human genome
G Manning et al.
SCIENCE (2002)
Imatinib: a selective tyrosine kinase inhibitor
PW Manley et al.
EUROPEAN JOURNAL OF CANCER (2002)
Inhibition of p38 MAP kinase by utilizing a novel allosteric binding site
C Pargellis et al.
NATURE STRUCTURAL BIOLOGY (2002)
Cloning and characterization of a p53-related protein kinase expressed in interleukin-2-activated cytotoxic T-cells, epithelial tumor cell lines, and the testes
Y Abe et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Discovery of a potent, highly selective, and orally efficacious small-molecule activator of the insulin receptor
K Liu et al.
JOURNAL OF MEDICINAL CHEMISTRY (2000)
Second-site NMR screening with a spin-labeled first ligand
W Jahnke et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2000)
Cross talk of pp125FAK and pp59Lyn non-receptor tyrosine kinases to insulin-mimetic signaling in adipocytes
G Müller et al.
MOLECULAR AND CELLULAR BIOLOGY (2000)
WNK1, a novel mammalian serine/threonine protein kinase lacking the catalytic lysine in subdomain II
BE Xu et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Peptide exosite inhibitors of factor VIIa as anticoagulants
MS Dennis et al.
NATURE (2000)