Related references
Note: Only part of the references are listed.Stable SREBP-1a knockdown decreases the cell proliferation rate in human preadipocyte cells without inducing senescence
Maria Soledad Alvarez et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2014)
MetDraw: automated visualization of genome-scale metabolic network reconstructions and high-throughput data
Paul A. Jensen et al.
BIOINFORMATICS (2014)
Cancer-associated fibroblasts induce epithelial-mesenchymal transition of breast cancer cells through paracrine TGF-β signalling
Y. Yu et al.
BRITISH JOURNAL OF CANCER (2014)
Blocking Lactate Export by Inhibiting the Myc Target MCT1 Disables Glycolysis and Glutathione Synthesis
Joanne R. Doherty et al.
CANCER RESEARCH (2014)
Akt-dependent Activation of mTORC1 Complex Involves Phosphorylation of mTOR (Mammalian Target of Rapamycin) by IκB Kinase α (IKKα)
Han C. Dan et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2014)
Metabolic model reconstruction and analysis of an artificial microbial ecosystem for vitamin C production
Chao Ye et al.
JOURNAL OF BIOTECHNOLOGY (2014)
A role for cancer-associated fibroblasts in inducing the epithelial-to-mesenchymal transition in human tongue squamous cell carcinoma
Bin Zhou et al.
JOURNAL OF ORAL PATHOLOGY & MEDICINE (2014)
Identification of anticancer drugs for hepatocellular carcinoma through personalized genome-scale metabolic modeling
Rasmus Agren et al.
MOLECULAR SYSTEMS BIOLOGY (2014)
Genome-scale metabolic network reconstruction and in silico flux analysis of the thermophilic bacterium Thermus thermophilus HB27
Na-Rae Lee et al.
MICROBIAL CELL FACTORIES (2014)
Integrated analysis of transcript-level regulation of metabolism reveals disease-relevant nodes of the human metabolic network
Mafalda Galhardo et al.
NUCLEIC ACIDS RESEARCH (2014)
Bottom-up Metabolic Reconstruction of Arabidopsis and Its Application to Determining the Metabolic Costs of Enzyme Production
Anne Arnold et al.
PLANT PHYSIOLOGY (2014)
Dynamics between Cancer Cell Subpopulations Reveals a Model Coordinating with Both Hierarchical and Stochastic Concepts
Weikang Wang et al.
PLOS ONE (2014)
Quantitative Measurement of Organic Acids in Tissues from Gastric Cancer Patients Indicates Increased Glucose Metabolism in Gastric Cancer
Hoon Hur et al.
PLOS ONE (2014)
Colorectal cancer derived organotypic spheroids maintain essential tissue characteristics but adapt their metabolism in culture
Uros Rajcevic et al.
PROTEOME SCIENCE (2014)
Targeting Unique Metabolic Properties of Breast Tumor Initiating Cells
Weiguo Feng et al.
STEM CELLS (2014)
Hexokinase 2 overexpression promotes the proliferation and survival of laryngeal squamous cell carcinoma
Jian Chen et al.
TUMOR BIOLOGY (2014)
Biochemical/metabolic changes associated with hepatocellular carcinoma development in mice
Nahla E. El-Ashmawy et al.
TUMOR BIOLOGY (2014)
Breast cancer stem cells rely on fermentative glycolysis and are sensitive to 2-deoxyglucose treatment
D. Ciavardelli et al.
CELL DEATH & DISEASE (2014)
GIM3E: condition-specific models of cellular metabolism developed from metabolomics and expression data
Brian J. Schmidt et al.
BIOINFORMATICS (2013)
Genomically and biochemically accurate metabolic reconstruction of Methanosarcina barkeri Fusaro, iMG746
Matthew C. Gonnerman et al.
BIOTECHNOLOGY JOURNAL (2013)
Adaptive bi-level programming for optimal gene knockouts for targeted overproduction under phenotypic constraints
Shaogang Ren et al.
BMC BIOINFORMATICS (2013)
An objective function exploiting suboptimal solutions in metabolic networks
Edwin H. Wintermute et al.
BMC SYSTEMS BIOLOGY (2013)
Creating a tumor-resistant microenvironment Cell-mediated delivery of TNFα completely prevents breast cancer tumor formation in vivo
Mazhar Al-Zoubi et al.
CELL CYCLE (2013)
ROS play a critical role in the differentiation of alternatively activated macrophages and the occurrence of tumor-associated macrophages
Yan Zhang et al.
CELL RESEARCH (2013)
Hypoxia Induces the Expression of Transketolase-Like 1 in Human Colorectal Cancer
S. Bentz et al.
DIGESTION (2013)
Endothelial cell metabolism and tumour angiogenesis: glucose and glutamine as essential fuels and lactate as the driving force
F. Polet et al.
JOURNAL OF INTERNAL MEDICINE (2013)
Cancer-generated lactic acid: a regulatory, immunosuppressive metabolite?
Stephen Yiu Chuen Choi et al.
JOURNAL OF PATHOLOGY (2013)
Genome-scale reconstruction and in silico analysis of Aspergillus terreus metabolism
Jie Liu et al.
MOLECULAR BIOSYSTEMS (2013)
Cross-talk between HIF and p53 as mediators of molecular responses to physiological and genotoxic stresses
Joanna Obacz et al.
MOLECULAR CANCER (2013)
Metabolic reconstruction identifies strain-specific regulation of virulence in Toxoplasma gondii
Carl Song et al.
MOLECULAR SYSTEMS BIOLOGY (2013)
A community-driven global reconstruction of human metabolism
Ines Thiele et al.
NATURE BIOTECHNOLOGY (2013)
Genome-scale reconstruction and in silico analysis of Klebsiella oxytoca for 2,3-butanediol production
Jong Myoung Park et al.
MICROBIAL CELL FACTORIES (2013)
Characterizing acetogenic metabolism using a genome-scale metabolic reconstruction of Clostridium ljungdahlii
Harish Nagarajan et al.
MICROBIAL CELL FACTORIES (2013)
Database resources of the National Center for Biotechnology Information
Abigail Acland et al.
NUCLEIC ACIDS RESEARCH (2013)
Targeting cellular metabolism to improve cancer therapeutics
Y. Zhao et al.
CELL DEATH & DISEASE (2013)
Model-based identification of drug targets that revert disrupted metabolism and its application to ageing
Keren Yizhak et al.
NATURE COMMUNICATIONS (2013)
The impact of molecular targets in cancer drug development: major hurdles and future strategies
Alexandra Hebar et al.
EXPERT REVIEW OF CLINICAL PHARMACOLOGY (2013)
Yeast 5-an expanded reconstruction of the Saccharomyces cerevisiae metabolic network
Benjamin D. Heavner et al.
BMC SYSTEMS BIOLOGY (2012)
Genome-scale metabolic reconstructions of Pichia stipitis and Pichia pastoris and in silico evaluation of their potentials
Luis Caspeta et al.
BMC SYSTEMS BIOLOGY (2012)
Reconstruction of genome-scale metabolic models for 126 human tissues using mCADRE
Yuliang Wang et al.
BMC SYSTEMS BIOLOGY (2012)
The fatty acid synthase inhibitor orlistat reduces experimental metastases and angiogenesis in B16-F10 melanomas
F. Seguin et al.
BRITISH JOURNAL OF CANCER (2012)
Endothelial cell metabolism and implications for cancer therapy
U. Harjes et al.
BRITISH JOURNAL OF CANCER (2012)
Cancer Statistics, 2012
Rebecca Siegel et al.
CA-A CANCER JOURNAL FOR CLINICIANS (2012)
VEGF-D Promotes Tumor Metastasis by Regulating Prostaglandins Produced by the Collecting Lymphatic Endothelium
Tara Karnezis et al.
CANCER CELL (2012)
Metabolic Reprogramming: A Cancer Hallmark Even Warburg Did Not Anticipate
Patrick S. Ward et al.
CANCER CELL (2012)
Metastatic Colonization Requires the Repression of the Epithelial-Mesenchymal Transition Inducer Prrx1
Oscar H. Ocana et al.
CANCER CELL (2012)
Metabolic Associations of Reduced Proliferation and Oxidative Stress in Advanced Breast Cancer
Livnat Jerby et al.
CANCER RESEARCH (2012)
Modulation of Microenvironment Acidity Reverses Anergy in Human and Murine Tumor-Infiltrating T Lymphocytes
Arianna Calcinotto et al.
CANCER RESEARCH (2012)
Cellular Metabolism and Disease: What Do Metabolic Outliers Teach Us?
Ralph J. DeBerardinis et al.
CELL (2012)
Metabolic remodeling of the tumor microenvironment Migration stimulating factor (MSF) reprograms myofibroblasts toward lactate production, fueling anabolic tumor growth
Valentina Carito et al.
CELL CYCLE (2012)
The Metabolic Profile of Tumors Depends on Both the Responsible Genetic Lesion and Tissue Type
Mariia O. Yuneva et al.
CELL METABOLISM (2012)
Inhibition of α-KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors
Mengtao Xiao et al.
GENES & DEVELOPMENT (2012)
Genome-Scale Metabolic Reconstruction and Hypothesis Testing in the Methanogenic Archaeon Methanosarcina acetivorans C2A
Matthew N. Benedict et al.
JOURNAL OF BACTERIOLOGY (2012)
Epithelial-mesenchymal transition can suppress major attributes of human epithelial tumor-initiating cells
Toni Celia-Terrassa et al.
JOURNAL OF CLINICAL INVESTIGATION (2012)
Systems medicine and metabolic modelling
A. Mardinoglu et al.
JOURNAL OF INTERNAL MEDICINE (2012)
The reconstruction and analysis of tissue specific human metabolic networks
Tong Hao et al.
MOLECULAR BIOSYSTEMS (2012)
Glutaminolysis Activates Rag-mTORC1 Signaling
Raul V. Duran et al.
MOLECULAR CELL (2012)
PHF20 is an effector protein of p53 double lysine methylation that stabilizes and activates p53
Gaofeng Cui et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2012)
The Genomes OnLine Database (GOLD) v.4: status of genomic and metagenomic projects and their associated metadata
Ioanna Pagani et al.
NUCLEIC ACIDS RESEARCH (2012)
KEGG for integration and interpretation of large-scale molecular data sets
Minoru Kanehisa et al.
NUCLEIC ACIDS RESEARCH (2012)
De-Meaning of Metabolism
Mitchell A. Lazar et al.
SCIENCE (2012)
Reconstruction of Genome-Scale Active Metabolic Networks for 69 Human Cell Types and 16 Cancer Types Using INIT
Rasmus Agren et al.
PLOS COMPUTATIONAL BIOLOGY (2012)
Phospholipase signalling networks in cancer
Jong Bae Park et al.
NATURE REVIEWS CANCER (2012)
Compartmentation of glycogen metabolism revealed from 13C isotopologue distributions
Igor Marin de Mas et al.
BMC SYSTEMS BIOLOGY (2011)
A multi-tissue type genome-scale metabolic network for analysis of whole-body systems physiology
Aarash Bordbar et al.
BMC SYSTEMS BIOLOGY (2011)
HRG Inhibits Tumor Growth and Metastasis by Inducing Macrophage Polarization and Vessel Normalization through Downregulation of PIGF
Charlotte Rolny et al.
CANCER CELL (2011)
Oncometabolite 2-Hydroxyglutarate Is a Competitive Inhibitor of α-Ketoglutarate-Dependent Dioxygenases
Wei Xu et al.
CANCER CELL (2011)
Lactate Influx through the Endothelial Cell Monocarboxylate Transporter MCT1 Supports an NF-κB/IL-8 Pathway that Drives Tumor Angiogenesis
Frederique Vegran et al.
CANCER RESEARCH (2011)
Hallmarks of Cancer: The Next Generation
Douglas Hanahan et al.
CELL (2011)
Metabolic engineering of Clostridium acetobutylicum: recent advances to improve butanol production
Tina Luetke-Eversloh et al.
CURRENT OPINION IN BIOTECHNOLOGY (2011)
Functional characterization of cancer-associated fibroblasts of human cutaneous squamous cell carcinoma
Suzan Commandeur et al.
EXPERIMENTAL DERMATOLOGY (2011)
CXCR4 peptide antagonist inhibits primary breast tumor growth, metastasis and enhances the efficacy of anti-VEGF treatment or docetaxel in a transgenic mouse model
Saima Hassan et al.
INTERNATIONAL JOURNAL OF CANCER (2011)
Geranylgeranyl diphosphate depletion inhibits breast cancer cell migration
Amel Dudakovic et al.
INVESTIGATIONAL NEW DRUGS (2011)
Metabolomics and Surgical Oncology: Potential Role for Small Molecule Biomarkers
Vanessa W. Davis et al.
JOURNAL OF SURGICAL ONCOLOGY (2011)
Predicting selective drug targets in cancer through metabolic networks
Ori Folger et al.
MOLECULAR SYSTEMS BIOLOGY (2011)
A comprehensive genome-scale reconstruction of Escherichia coli metabolism-2011
Jeffrey D. Orth et al.
MOLECULAR SYSTEMS BIOLOGY (2011)
Integrative genome-scale metabolic analysis of Vibrio vulnificus for drug targeting and discovery
Hyun Uk Kim et al.
MOLECULAR SYSTEMS BIOLOGY (2011)
Haem oxygenase is synthetically lethal with the tumour suppressor fumarate hydratase
Christian Frezza et al.
NATURE (2011)
p53 regulates biosynthesis through direct inactivation of glucose-6-phosphate dehydrogenase
Peng Jiang et al.
NATURE CELL BIOLOGY (2011)
Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth
Kristin M. Nieman et al.
NATURE MEDICINE (2011)
Direct targeting of Sec23a by miR-200s influences cancer cell secretome and promotes metastatic colonization
Manav Korpal et al.
NATURE MEDICINE (2011)
Quantitative prediction of cellular metabolism with constraint-based models: the COBRA Toolbox v2.0
Jan Schellenberger et al.
NATURE PROTOCOLS (2011)
Antiangiogenic therapy, hypoxia, and metastasis: risky liaisons, or not?
Katrien De Bock et al.
NATURE REVIEWS CLINICAL ONCOLOGY (2011)
Systems-biology approaches for predicting genomic evolution
Balazs Papp et al.
NATURE REVIEWS GENETICS (2011)
Network medicine: a network-based approach to human disease
Albert-Laszlo Barabasi et al.
NATURE REVIEWS GENETICS (2011)
Engineering strategy of yeast metabolism for higher alcohol production
Fumio Matsuda et al.
MICROBIAL CELL FACTORIES (2011)
C-X-C receptor type 4 promotes metastasis by activating p38 mitogen-activated protein kinase in myeloid differentiation antigen (Gr-1)-positive cells
Sachie Hiratsuka et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
Exploring the Genomes of Cancer Cells: Progress and Promise
Michael R. Stratton
SCIENCE (2011)
Cancer cells release glutamate via the cystine/glutamate antiporter
Mohit K. Sharma et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2010)
Identification of small molecule inhibitors of pyruvate kinase M2
Matthew G. Vander Heiden et al.
BIOCHEMICAL PHARMACOLOGY (2010)
Metabolic network adaptations in cancer as targets for novel therapies
Marta Cascante et al.
BIOCHEMICAL SOCIETY TRANSACTIONS (2010)
iMAT: an integrative metabolic analysis tool
Hadas Zur et al.
BIOINFORMATICS (2010)
A detailed genome-wide reconstruction of mouse metabolism based on human Recon 1
Martin I. Sigurdsson et al.
BMC SYSTEMS BIOLOGY (2010)
Anti-Placental Growth Factor Reduces Bone Metastasis by Blocking Tumor Cell Engraftment and Osteoclast Differentiation
Lieve Coenegrachts et al.
CANCER RESEARCH (2010)
Aberrant Activation of Fatty Acid Synthesis Suppresses Primary Cilium Formation and Distorts Tissue Development
Nicolas Willemarck et al.
CANCER RESEARCH (2010)
Monoacylglycerol Lipase Regulates a Fatty Acid Network that Promotes Cancer Pathogenesis
Daniel K. Nomura et al.
CELL (2010)
The autophagic tumor stroma model of cancer Role of oxidative stress and ketone production in fueling tumor cell metabolism
Stephanos Pavlides et al.
CELL CYCLE (2010)
Glutaminolysis Supplying carbon or nitrogen or both for cancer cells?
Chi V. Dang
CELL CYCLE (2010)
Warburg effect in chemosensitivity: Targeting lactate dehydrogenase-A re-sensitizes Taxol-resistant cancer cells to Taxol
Ming Zhou et al.
MOLECULAR CANCER (2010)
Large-scale in silico modeling of metabolic interactions between cell types in the human brain
Nathan E. Lewis et al.
NATURE BIOTECHNOLOGY (2010)
High-throughput generation, optimization and analysis of genome-scale metabolic models
Christopher S. Henry et al.
NATURE BIOTECHNOLOGY (2010)
What is flux balance analysis?
Jeffrey D. Orth et al.
NATURE BIOTECHNOLOGY (2010)
Messy biology and the origins of evolutionary innovations
Dan S. Tawfik
NATURE CHEMICAL BIOLOGY (2010)
The MetaCyc database of metabolic pathways and enzymes and the BioCyc collection of pathway/genome databases
Ron Caspi et al.
NUCLEIC ACIDS RESEARCH (2010)
C4GEM, a Genome-Scale Metabolic Model to Study C4 Plant Metabolism
Cristiana Gomes de Oliveira Dal'Molin et al.
PLANT PHYSIOLOGY (2010)
Probabilistic integrative modeling of genome-scale metabolic and regulatory networks in Escherichia coli and Mycobacterium tuberculosis
Sriram Chandrasekaran et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression
Anne Le et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Heterogeneity of the Tumor Vasculature
Janice A. Nagy et al.
SEMINARS IN THROMBOSIS AND HEMOSTASIS (2010)
IDH mutations in glioma and acute myeloid leukemia
Lenny Dang et al.
TRENDS IN MOLECULAR MEDICINE (2010)
Human synthetic lethal inference as potential anti-cancer target gene detection
Nuria Conde-Pueyo et al.
BMC SYSTEMS BIOLOGY (2009)
Characterization of the metabolic changes underlying growth factor angiogenic activation: identification of new potential therapeutic targets
Pedro Vizan et al.
CARCINOGENESIS (2009)
Heterozygous Deficiency of PHD2 Restores Tumor Oxygenation and Inhibits Metastasis via Endothelial Normalization
Massimiliano Mazzone et al.
CELL (2009)
Changes in Human Endothelial Cell Energy Metabolic Capacities during in vitro Cultivation. The Role of Aerobic Glycolysis and Proliferation
Kirsten Peters et al.
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2009)
Modulation of pentose phosphate pathway during cell cycle progression in human colon adenocarcinoma cell line HT29
Pedro Vizan et al.
INTERNATIONAL JOURNAL OF CANCER (2009)
Transketolase-like protein 1 (TKTL1) is required for rapid cell growth and full viability of human tumor cells
Xiaojun Xu et al.
INTERNATIONAL JOURNAL OF CANCER (2009)
Use of Randomized Sampling for Analysis of Metabolic Networks
Jan Schellenberger et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Capturing the essence of a metabolic network: A flux balance analysis approach
Ettore Murabito et al.
JOURNAL OF THEORETICAL BIOLOGY (2009)
Reconstruction of biochemical networks in microorganisms
Adam M. Feist et al.
NATURE REVIEWS MICROBIOLOGY (2009)
IDH1 and IDH2 Mutations in Gliomas
Hai Yan et al.
NEW ENGLAND JOURNAL OF MEDICINE (2009)
BRENDA, AMENDA and FRENDA the enzyme information system: new content and tools in 2009
Antje Chang et al.
NUCLEIC ACIDS RESEARCH (2009)
Inhibition of Hedgehog Signaling Enhances Delivery of Chemotherapy in a Mouse Model of Pancreatic Cancer
Kenneth P. Olive et al.
SCIENCE (2009)
Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
Matthew G. Vander Heiden et al.
SCIENCE (2009)
GrowMatch: An Automated Method for Reconciling In Silico/In Vivo Growth Predictions
Vinay Satish Kumar et al.
PLOS COMPUTATIONAL BIOLOGY (2009)
The pervasive presence of fluctuating oxygenation in tumors
Laura I. Cardenas-Navia et al.
CANCER RESEARCH (2008)
Fatty acid synthase gene is up-regulated by hypoxia via activation of Akt and sterol regulatory element binding protein-1
Eiji Furuta et al.
CANCER RESEARCH (2008)
SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth
Thomas Porstmann et al.
CELL METABOLISM (2008)
Migratory neighbors and distant invaders: tumor-associated niche cells
Jared Wels et al.
GENES & DEVELOPMENT (2008)
Induction of pyruvate dehydrogenase kinase-3 by hypoxia-inducible factor-1 promotes metabolic switch and drug resistance
Chun-Wun Lu et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Small-molecule inhibition of 6-phosphofructo-2-kinase activity suppresses glycolytic flux and tumor growth
Brian Clem et al.
MOLECULAR CANCER THERAPEUTICS (2008)
Pyruvate kinase M2 is a phosphotyrosine-binding protein
Heather R. Christofk et al.
NATURE (2008)
The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth
Heather R. Christofk et al.
NATURE (2008)
Disruption of the hexokinase - VDAC complex for tumor therapy
L. Galluzzi et al.
ONCOGENE (2008)
Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction
David R. Wise et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Regulation of GLUT3 and glucose uptake by the cAMP signalling pathway in the breast cancer cell line ZR-75
Ana Maria Meneses et al.
JOURNAL OF CELLULAR PHYSIOLOGY (2008)
Snail, ZEB and bHLH factors in tumour progression: an alliance against the epithelial phenotype?
Hector Peinado et al.
NATURE REVIEWS CANCER (2007)
Global reconstruction of the human metabolic network based on genomic and bibliomic data
Natalie C. Duarte et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Lethality in Drosophila melanogaster/Drosophila simulans species hybrids is not associated with substantial transcriptional misregulation
Daniel A. Barbash et al.
JOURNAL OF EXPERIMENTAL ZOOLOGY PART B-MOLECULAR AND DEVELOPMENTAL EVOLUTION (2007)
Mitochondrial hexokinases, novel mediators of the antiapoptotic effects of growth factors and Akt
R. B. Robey et al.
ONCOGENE (2006)
Tumor microenvironmental physiology and its implications for radiation oncology
P Vaupel
SEMINARS IN RADIATION ONCOLOGY (2004)