Related references
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ANESTHESIOLOGY (2013)
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BIOORGANIC & MEDICINAL CHEMISTRY (2013)
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BIOORGANIC & MEDICINAL CHEMISTRY (2013)
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BIOORGANIC & MEDICINAL CHEMISTRY (2013)
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BIOORGANIC & MEDICINAL CHEMISTRY (2013)
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BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2013)
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BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2013)
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BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2013)
Safety, tolerability and pharmacokinetics of single and multiple doses of a novel sigma-1 receptor antagonist in three randomized phase I studies
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BRITISH JOURNAL OF CLINICAL PHARMACOLOGY (2013)
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EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2013)
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EUROPEAN JOURNAL OF PAIN (2013)
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Agmatine attenuates neuropathic pain in sciatic nerve ligated rats: Modulation by hippocampal sigma receptors
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Sigma-1 receptor-mediated increase in spinal p38 MAPK phosphorylation leads to the induction of mechanical allodynia in mice and neuropathic rats
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EXPERIMENTAL NEUROLOGY (2013)
Sigma receptor modulators: a patent review
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EXPERT OPINION ON THERAPEUTIC PATENTS (2013)
The evaluation of AZ66, an optimized sigma receptor antagonist, against methamphetamine-induced dopaminergic neurotoxicity and memory impairment in mice
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INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY (2013)
Characterization of the Human Sigma-1 Receptor Chaperone Domain Structure and Binding Immunoglobulin Protein (BiP) Interactions
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JOURNAL OF BIOLOGICAL CHEMISTRY (2013)
Synthesis and Biological Evaluation of a New Series of Hexahydro-2H-pyrano[3,2-c]quinolines as Novel Selective σ1 Receptor Ligands
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JOURNAL OF MEDICINAL CHEMISTRY (2013)
Structure of the σ1 Receptor and Its Ligand Binding Site Miniperspective
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JOURNAL OF MEDICINAL CHEMISTRY (2013)
The σ2 Receptor: A Novel Protein for the Imaging and Treatment of Cancer
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JOURNAL OF MEDICINAL CHEMISTRY (2013)
The σ-1 Receptor Interacts Directly with GluN1 But Not GluN2A in the GluN1/GluN2A NMDA Receptor
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JOURNAL OF NEUROSCIENCE (2013)
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JOURNAL OF PHARMACOLOGICAL SCIENCES (2013)
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NEUROPHARMACOLOGY (2013)
Cocaine Inhibits Dopamine D2 Receptor Signaling via Sigma-1-D2 Receptor Heteromers
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PLOS ONE (2013)
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MOLECULAR PHARMACOLOGY (2013)
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BIOORGANIC & MEDICINAL CHEMISTRY (2012)
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BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2012)
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BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2012)
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BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2012)
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BRITISH JOURNAL OF PHARMACOLOGY (2012)
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CURRENT PHARMACEUTICAL DESIGN (2012)
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CURRENT PHARMACEUTICAL DESIGN (2012)
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CURRENT PHARMACEUTICAL DESIGN (2012)
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JOURNAL OF MEDICINAL CHEMISTRY (2012)
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JOURNAL OF MEDICINAL CHEMISTRY (2012)
The σ1 Receptor Antagonist S1RA Is a Promising Candidate for the Treatment of Neurogenic Pain
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JOURNAL OF MEDICINAL CHEMISTRY (2012)
New Positron Emission Tomography (PET) Radioligand for Imaging σ-1 Receptors in Living Subjects
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JOURNAL OF MEDICINAL CHEMISTRY (2012)
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JOURNAL OF MEDICINAL CHEMISTRY (2012)
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JOURNAL OF MEDICINAL CHEMISTRY (2012)
Role of Sigma-1 Receptors in Paclitaxel-Induced Neuropathic Pain in Mice
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JOURNAL OF PAIN (2012)
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MOLECULAR PHARMACEUTICS (2012)
Models of the pharmacophoric pattern and affinity trend of methyl 2-(aminomethyl)-1-phenylcyclopropane-1-carboxylate derivatives as σ1 ligands
Julio Caballero et al.
MOLECULAR SIMULATION (2012)
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Aashish Manglik et al.
NATURE (2012)
New Adamantane Derivatives with Sigma Affinity and Antiproliferative Activity
Stefanos Riganas et al.
MEDICINAL CHEMISTRY (2012)
Sigma-1R Agonist Improves Motor Function and Motoneuron Survival in ALS Mice
Renzo Mancuso et al.
NEUROTHERAPEUTICS (2012)
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Michiko Fujimoto et al.
SYNAPSE (2012)
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ACS MEDICINAL CHEMISTRY LETTERS (2012)
Synthesis and Pharmacological Evaluation of a Potent and Selective σ1 Receptor Antagonist with High Antiallodynic Activity
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ARCHIV DER PHARMAZIE (2011)
Synthesis and binding assays of novel 3,3-dimethylpiperidine derivatives with various lipophilicities as σ1 receptor ligands
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BIOORGANIC & MEDICINAL CHEMISTRY (2011)
Pain as a global public health priority
Daniel S. Goldberg et al.
BMC PUBLIC HEALTH (2011)
Synthesis of 4-(aminoalkyl) substituted 1,3-dioxanes as potent NMDA and σ receptor antagonists
Tina Utech et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2011)
Targeting ligand-operated chaperone sigma-1 receptors in the treatment of neuropsychiatric disorders
Teruo Hayashi et al.
EXPERT OPINION ON THERAPEUTIC TARGETS (2011)
Early development of sigma-receptor ligands
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FUTURE MEDICINAL CHEMISTRY (2011)
Combination of Two Pharmacophoric Systems: Synthesis and Pharmacological Evaluation of Spirocyclic Pyranopyrazoles with High σ1 Receptor Affinity
Torsten Schlaeger et al.
JOURNAL OF MEDICINAL CHEMISTRY (2011)
Novel Potent and Selective σ Ligands: Evaluation of Their Agonist and Antagonist Properties
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JOURNAL OF MEDICINAL CHEMISTRY (2011)
Combination Drug Therapy for Chronic Pain: A Call for More Clinical Studies
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JOURNAL OF PAIN (2011)
Anti-amnesic and neuroprotective potentials of the mixed muscarinic receptor/sigma1 (σ1) ligand ANAVEX2-73, a novel aminotetrahydrofuran derivative
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JOURNAL OF PSYCHOPHARMACOLOGY (2011)
Treatment of chronic non-cancer pain
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LANCET (2011)
The dipeptide Phe-Phe amide attenuates signs of hyperalgesia, allodynia and nociception in diabetic mice using a mechanism involving the sigma receptor system
Masahiro Ohsawa et al.
MOLECULAR PAIN (2011)
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Erik Laurini et al.
ACS MEDICINAL CHEMISTRY LETTERS (2011)
Identification of the PGRMC1 protein complex as the putative sigma-2 receptor binding site
Jinbin Xu et al.
NATURE COMMUNICATIONS (2011)
Demonstration of a Direct Interaction between σ-1 Receptors and Acid-Sensing Ion Channels
Stewart M. Carnally et al.
BIOPHYSICAL JOURNAL (2010)
Sigma Receptors in Oncology: Therapeutic and Diagnostic Applications of Sigma Ligands
Aren van Waarde et al.
CURRENT PHARMACEUTICAL DESIGN (2010)
Lipophilicity in drug discovery
Michael J. Waring
EXPERT OPINION ON DRUG DISCOVERY (2010)
Pharmacological and metabolic characterisation of the potent σ1 receptor ligand 1′-benzyl-3-methoxy-3H-spiro[[2]benzofuran-1,4′-piperidine]
Christian Wiese et al.
JOURNAL OF PHARMACY AND PHARMACOLOGY (2010)
Sigma-1 Receptor Antagonist BD1047 Reduces Allodynia and Spinal ERK Phosphorylation Following Chronic Compression of Dorsal Root Ganglion in Rats
Ji Seon Son et al.
KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY (2010)
σ1 Receptor Modulation of G-Protein-Coupled Receptor Signaling: Potentiation of Opioid Transduction Independent from Receptor Binding
Felix J. Kim et al.
MOLECULAR PHARMACOLOGY (2010)
Direct involvement of σ-1 receptors in the dopamine D1 receptor-mediated effects of cocaine
Gemma Navarro et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
The sigma-1 receptor chaperone as an inter-organelle signaling modulator
Tsung-Ping Su et al.
TRENDS IN PHARMACOLOGICAL SCIENCES (2010)
Synthesis, Biological Evaluation, and Three-Dimensional in Silico Pharmacophore Model for σ1 Receptor Ligands Based on a Series of Substituted Benzo[d]oxazol-2(3H)-one Derivatives
Daniele Zampieri et al.
JOURNAL OF MEDICINAL CHEMISTRY (2009)
The Antinociceptive Effect of Sigma-1 Receptor Antagonist, BD1047, in a Capsaicin Induced Headache Model in Rats
Young Bae Kwon et al.
KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY (2009)
Sigma-1 receptors regulate activity-induced spinal sensitization and neuropathic pain after peripheral nerve injury
Beatriz de la Puente et al.
PAIN (2009)
Sigma-1 receptors are essential for capsaicin-induced mechanical hypersensitivity: Studies with selective sigma-1 ligands and sigma-1 knockout mice
Jose Manuel Entrena et al.
PAIN (2009)
The pharmacology of sigma-1 receptors
Tangui Maurice et al.
PHARMACOLOGY & THERAPEUTICS (2009)
Intrathecal Injection of the σ1 Receptor Antagonist BD1047 Blocks Both Mechanical Allodynia and Increases in Spinal NR1 Expression during the Induction Phase of Rodent Neuropathic Pain
Dae-Hyun Roh et al.
ANESTHESIOLOGY (2008)
Probing the steroid binding domain-like I (SBDLI) of the sigma-1 receptor binding site using N-substituted photoaffinity labels
Dominique Fontanilla et al.
BIOCHEMISTRY (2008)
Role of sigma-1 receptor C-terminal segment in inositol 1,4,5-trisphosphate receptor activation - Constitutive enhancement of calcium signaling in MCF-7 tumor cells
Zhiping Wu et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Juxtaposition of the steroid binding domain-like I and II regions constitutes a ligand binding site in the σ-1 receptor
Arindam Pal et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Thiophene Bioisosteres of Spirocyclic σ Receptor Ligands. 1. N-Substituted Spiro[piperidine-4,4′-thieno[3,2-c]pyrans]
Christoph Oberdorf et al.
JOURNAL OF MEDICINAL CHEMISTRY (2008)
Sigma-1 Receptor Regulation of Voltage-Gated Calcium Channels Involves a Direct Interaction
Kissaou T. Tchedre et al.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2008)
Sigma-1 receptors bind cholesterol and remodel lipid rafts in breast cancer cell lines
Christopher P. Palmer et al.
CANCER RESEARCH (2007)
Sigma-1 receptor chaperones at the ER-Mitochondrion interface regulate Ca2+ signaling and cell survival
Teruo Hayashi et al.
CELL (2007)
Characterization of the cocaine binding site on the sigma-1 receptor
Yuenmu Chen et al.
BIOCHEMISTRY (2007)
Intrathecal treatment with σ1 receptor antagonists reduces formalin-induced phosphorylation of NMDA receptor subunit 1 and the second phase of formalin test in mice
Hyun-Woo Kim et al.
BRITISH JOURNAL OF PHARMACOLOGY (2006)
In vivo evaluation of (+)-MR200 as a new selective sigma ligand modulating MOP, DOP and KOP supraspinal analgesia
A Marrazzo et al.
LIFE SCIENCES (2006)
A medicinal-chemistry-guided approach to selective and druglike sigma 1 ligands
Jordi Corbera et al.
CHEMMEDCHEM (2006)
Discovery of high-affinity ligands of σ1 receptor, ERG2, and emopamil binding protein by pharmacophore modeling and virtual screening
C Laggner et al.
JOURNAL OF MEDICINAL CHEMISTRY (2005)
Formalin-induced pain is reduced in σ1 receptor knockout mice
CM Cendán et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2005)
Phenytoin differentially modulates the affinity of agonist and antagonist ligands for σ1 receptors of guinea pig brain
EJ Cobos et al.
SYNAPSE (2005)
Generation and phenotypic analysis of sigma receptor type I (σ1) knockout mice
F Langa et al.
EUROPEAN JOURNAL OF NEUROSCIENCE (2003)
The sigma receptor as a ligand-regulated auxiliary potassium channel subunit
E Aydar et al.
NEURON (2002)
Expression pattern of the type 1 sigma receptor in the brain and identity of critical anionic amino acid residues in the ligand-binding domain of the receptor
P Seth et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2001)