Journal
FUTURE MEDICINAL CHEMISTRY
Volume 6, Issue 12, Pages 1413-1422Publisher
Newlands Press Ltd
DOI: 10.4155/FMC.14.86
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Funding
- NIH [RO1AR47901]
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So-called antioxidants have yet to make a clinical impact on the treatment of human cancer. The reasons for this failure are several. First, many agents that are called antioxidants are truly antioxidants at a given dose, but this dose may not have been given in clinical trials. Second, many agents are not antioxidants at all. Third, not all tumors use reactive oxygen as a signaling mechanism. Finally, reactive oxygen inhibition is often insufficient to kill or regress a tumor cell by itself, but requires sequential introduction of a therapeutic agent for maximal effect. We hope to provide a framework for the logical use of these agents in cancer.
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