Journal
FUTURE MEDICINAL CHEMISTRY
Volume 4, Issue 14, Pages 1811-1822Publisher
FUTURE SCI LTD
DOI: 10.4155/FMC.12.115
Keywords
-
Categories
Funding
- NICHD NIH HHS [R44 HD047089, R43 HD047089] Funding Source: Medline
- NIDDK NIH HHS [R41 DK082060] Funding Source: Medline
- NIMH NIH HHS [R21 MH083614] Funding Source: Medline
- NINDS NIH HHS [R43 NS067916] Funding Source: Medline
Ask authors/readers for more resources
Due to several inherent advantages, zebrafish are being utilized in increasingly sophisticated screens to assess the physiological effects of chemical compounds directly in living vertebrate organisms. Diverse screening platforms showcase these advantages. Morphological assays encompassing basic qualitative observations to automated imaging, manipulation, and data-processing systems provide whole organism to subcellular levels of detail. Behavioral screens extend chemical screening to the level of complex systems. In addition, zebrafish-based disease models provide a means of identifying new potential therapeutic strategies. Automated systems for handling/sorting, high-resolution imaging and quantitative data collection have significantly increased throughput in recent years. These advances will make it easier to capture multiple streams of information from a given sample and facilitate integration of zebrafish at the earliest stages of the drug-discovery process, providing potential solutions to current drug-development bottlenecks. Here we outline advances that have been made within the growing field of zebrafish chemical screening.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available