Related references
Note: Only part of the references are listed.A Dynamic Knockout Reveals That Conformational Fluctuations Influence the Chemical Step of Enzyme Catalysis
Gira Bhabha et al.
SCIENCE (2011)
Efavirenz Binding to HIV-1 Reverse Transcriptase Monomers and Dimers
Valerie A. Braz et al.
BIOCHEMISTRY (2010)
Ligand binding assays at equilibrium: validation and interpretation
Edward C. Hulme et al.
BRITISH JOURNAL OF PHARMACOLOGY (2010)
Drug-target residence time: critical information for lead optimization
Hao Lu et al.
CURRENT OPINION IN CHEMICAL BIOLOGY (2010)
The dynamics of drug-target interactions: drug-target residence time and its impact on efficacy and safety
Robert A. Copeland
EXPERT OPINION ON DRUG DISCOVERY (2010)
Slow Onset Inhibition of Bacterial β-Ketoacyl-acyl Carrier Protein Synthases by Thiolactomycin
Carl A. Machutta et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Dynamics connect substrate recognition to catalysis in protein kinase A
Larry R. Masterson et al.
NATURE CHEMICAL BIOLOGY (2010)
Biochemical characterization of GSK1070916, a potent and selective inhibitor of Aurora B and Aurora C kinases with an extremely long residence time
Kelly Anderson et al.
BIOCHEMICAL JOURNAL (2009)
Inhibition and Binding Kinetics of the Hepatitis C Virus NS3 Protease Inhibitor ITMN-191 Reveals Tight Binding and Slow Dissociative Behavior
Ravi Rajagopalan et al.
BIOCHEMISTRY (2009)
Potent Inhibitors of HIV-1 Integrase Display a Two-Step, Slow-Binding Inhibition Mechanism Which Is Absent in a Drug-Resistant T66I/M154I Mutant
Edward P. Garvey et al.
BIOCHEMISTRY (2009)
Structural biology contributions to tyrosine kinase drug discovery
Sandra W. Cowan-Jacob et al.
CURRENT OPINION IN CELL BIOLOGY (2009)
Early integration of pharmacokinetic and dynamic reasoning is essential for optimal development of lead compounds: strategic considerations
Johan Gabrielsson et al.
DRUG DISCOVERY TODAY (2009)
The role of dynamic conformational ensembles in biomolecular recognition
David D. Boehr et al.
NATURE CHEMICAL BIOLOGY (2009)
Conformational selection or induced fit: A flux description of reaction mechanism
Gordon G. Hammes et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Selected-fit versus induced-fit protein binding: Kinetic differences and mutational analysis
Thomas R. Weikl et al.
PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS (2009)
Residence time of receptor-ligand complexes and its effect on biological function
Peter J. Tummino et al.
BIOCHEMISTRY (2008)
Pseudoirreversible Inhibition of Prostate-Specific Membrane Antigen by Phosphoramidate Peptidomimetics
Tiancheng Liu et al.
BIOCHEMISTRY (2008)
Mechanism of inhibition of human KSP by Ispinesib
Latesh Lad et al.
BIOCHEMISTRY (2008)
Characterization of an Akt kinase inhibitor with potent pharmacodynamic and antitumor activity
Nelson Rhodes et al.
CANCER RESEARCH (2008)
Enzymes with lid-gated active sites must operate by an induced fit mechanism instead of conformational selection
Sarah M. Sullivan et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Binding kinetics of darunavir to human immunodeficiency virus type 1 protease explain the potent antiviral activity and high genetic barrier
Inge Dierynck et al.
JOURNAL OF VIROLOGY (2007)
Binding of TPX2 to aurora a alters substrate and inhibitor interactions
Kelly Anderson et al.
BIOCHEMISTRY (2007)
Induced-fit tightens pleuromutilins binding to ribosomes and remote interactions enable their selectivity
Chen Davidovich et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
A pre-steady state analysis of ligand binding to human glucokinase: Evidence for a preexisting equilibrium
Young B. Kim et al.
BIOCHEMISTRY (2007)
Opinion - Drug-target residence time and its implications for lead optimization
Robert A. Copeland et al.
NATURE REVIEWS DRUG DISCOVERY (2006)
Slow antagonist dissociation and long-lasting in vivo receptor protection
Georges Vauquelin et al.
TRENDS IN PHARMACOLOGICAL SCIENCES (2006)
A biochemical rationale for the anticancer effects of Hsp90 inhibitors: Slow, tight binding inhibition by geldanamycin and its analogues
Lata T. Gooljarsingh et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Preclinical profile of VX-950, a potent, selective, and orally bioavailable inhibitor of hepatitis C virus NS3-4A serine protease
RB Perni et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2006)
Discovery and clinical development of dutasteride, a potent dual 5 alpha-reductase inhibitor
Stephen V. Frye
CURRENT TOPICS IN MEDICINAL CHEMISTRY (2006)
A slow, tight-binding inhibitor of the zinc-dependent deacetylase LpxC of lipid a biosynthesis with antibiotic activity comparable to ciprofloxacin
AL McClerren et al.
BIOCHEMISTRY (2005)
Mechanism of time-dependent inhibition of polypeptide deformylase by actinonin
GS Van Aller et al.
BIOCHEMISTRY (2005)
Hepatitis CNS3 protease inhibition by peptidyl-α-ketoamide inhibitors:: kinetic mechanism and structure
YY Liu et al.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2004)
A unique structure for epidermal growth factor receptor bound to GW572016 (Lapatinib): Relationships among protein conformation, inhibitor off-rate, and receptor activity in tumor cells
ER Wood et al.
CANCER RESEARCH (2004)
Biochemical mechanisms of drug action: what does it take for success?
DC Swinney
NATURE REVIEWS DRUG DISCOVERY (2004)
Kinetic and structural analysis of the increased affinity of enoyl-ACP (acyl-carrier protein) reductase for triclosan in the presence of NAD+
M Kapoor et al.
BIOCHEMICAL JOURNAL (2004)
The isoniazid-NAD adduct is a slow, tight-binding inhibitor of InhA, the Mycobacterium tuberculosis enoyl reductase:: Adduct affinity and drug resistance
R Rawat et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
The relationship between side reactions and slow inhibition of ribulose-bisphosphate carboxylase revealed by a loop 6 mutant of the tobacco enzyme
FG Pearce et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Molecular mechanism for inhibition of 3-hydroxy-3-methylglutaryl CoA (HMG-CoA) reductase by rosuvastatin
GA Holdgate et al.
BIOCHEMICAL SOCIETY TRANSACTIONS (2003)
Arninophosphonate inhibitors of dialkylglycine decarboxylase: Structural basis for slow binding inhibition
WS Liu et al.
BIOCHEMISTRY (2002)
Novel inhibition of porcine pepsin by a substituted piperidine - Preference for one of the enzyme conformers
J Marcinkeviciene et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Mutagenesis and mechanism-based inhibition of Streptococcus pyogenes Glu-tRNAGln amidotransferase implicate a serine-based glutaminase site
MR Harpel et al.
BIOCHEMISTRY (2002)
Slow-tight binding inhibition of xylanase by an aspartic protease inhibitor - Kinetic parameters and conformational changes that determine the affinity and selectivity of the bifunctional nature of the inhibitor's
C Dash et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Inhibition of p38 MAP kinase by utilizing a novel allosteric binding site
C Pargellis et al.
NATURE STRUCTURAL BIOLOGY (2002)
The inactivation of lipoxygenase-1 from soybeans by amidrazones
F Clemens et al.
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEIN STRUCTURE AND MOLECULAR ENZYMOLOGY (2001)
Purine nucleoside phosphorylase from Mycobacterium tuberculosis.: Analysis of inhibition by a transition-state analogue and dissection by parts
LA Basso et al.
BIOCHEMISTRY (2001)
Mechanism of inhibition of β-site amyloid precursor protein-cleaving enzyme (BACE) by a statine-based peptide
J Marcinkeviciene et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
The crystal structure of tetrameric methionine adenosyltransferase from rat liver reveals the methionine-binding site
B González et al.
JOURNAL OF MOLECULAR BIOLOGY (2000)