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Bareket Dassa et al.
NUCLEIC ACIDS RESEARCH (2009)
High-resolution profiling of homing endonuclease binding and catalytic specificity using yeast surface display
Jordan Jarjour et al.
NUCLEIC ACIDS RESEARCH (2009)
Crystal structure of the -Me type II restriction endonuclease Hpy99I with target DNA
Monika Sokolowska et al.
NUCLEIC ACIDS RESEARCH (2009)
Targeted correction of a thalassemia-associated -globin mutation induced by pseudo-complementary peptide nucleic acids
Pallavi Lonkar et al.
NUCLEIC ACIDS RESEARCH (2009)
High-affinity triplex targeting of double stranded DNA using chemically modified peptide nucleic acid oligomers
Mads E. Hansen et al.
NUCLEIC ACIDS RESEARCH (2009)
Zinc Finger Database (ZiFDB): a repository for information on C2H2 zinc fingers and engineered zinc-finger arrays
Fengli Fu et al.
NUCLEIC ACIDS RESEARCH (2009)
Efficient targeting of a SCID gene by an engineered single-chain homing endonuclease
Sylvestre Grizot et al.
NUCLEIC ACIDS RESEARCH (2009)
UN-induced mutagenesis and gene-targeting in Arabidopsis through Agrobacterium-mediated floral dip transformation
Sylvia de Pater et al.
PLANT BIOTECHNOLOGY JOURNAL (2009)
A toolbox and procedural notes for characterizing novel zinc finger nucleases for genome editing in plant cells
Andriy Tovkach et al.
PLANT JOURNAL (2009)
Targeted transgene integration in plant cells using designed zinc finger nucleases
Charles Q. Cai et al.
PLANT MOLECULAR BIOLOGY (2009)
Targeted mutagenesis in the progeny of maize transgenic plants
Meizhu Yang et al.
PLANT MOLECULAR BIOLOGY (2009)
Rapid Mutation of Endogenous Zebrafish Genes Using Zinc Finger Nucleases Made by Oligomerized Pool ENgineering (OPEN)
Jonathan E. Foley et al.
PLOS ONE (2009)
Redox signaling between DNA repair proteins for efficient lesion detection
Amie K. Boal et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Synthesis of programmable integrases
Russell M. Gordley et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Directed, efficient, and versatile modifications of the Drosophila genome by genomic engineering
Juan Huang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Generation of a nicking enzyme that stimulates site-specific gene conversion from the I-AniI LAGLIDADG homing endonuclease
Audrey McConnell Smith et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Chromosomal translocations induced at specified loci in human stem cells
Erika Brunet et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Zinc-finger directed double-strand breaks within CAG repeat tracts promote repeat instability in human cells
David Mittelman et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Prediction of 3D metal binding sites from translated gene sequences based on remote-homology templates
Ronen Levy et al.
PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS (2009)
Breaking the Code of DNA Binding Specificity of TAL-Type III Effectors
Jens Boch et al.
SCIENCE (2009)
A Simple Cipher Governs DNA Recognition by TAL Effectors
Matthew J. Moscou et al.
SCIENCE (2009)
The Structure of a Bacterial DUF199/WhiA Protein: Domestication of an Invasive Endonuclease
Brett K. Kaiser et al.
STRUCTURE (2009)
Nucleases and helicases take center stage in homologous recombination
Eleni P. Mimitou et al.
TRENDS IN BIOCHEMICAL SCIENCES (2009)
DNA repair: easy to visualize, difficult to elucidate
Zita Nagy et al.
TRENDS IN CELL BIOLOGY (2009)
Design of artificial nucleases and studies of their interaction with DNA
Zhang JingJing et al.
SCIENCE IN CHINA SERIES B-CHEMISTRY (2009)
Attenuation of Zinc Finger Nuclease Toxicity by Small-Molecule Regulation of Protein Levels
Shondra M. Pruett-Miller et al.
PLOS GENETICS (2009)
A High Throughput Genetic Screen Identifies New Early Meiotic Recombination Functions in Arabidopsis thaliana
Arnaud De Muyt et al.
PLOS GENETICS (2009)
Targeting DNA 5mCpG sites with chimeric endonucleases
Alexey Fomenkov et al.
ANALYTICAL BIOCHEMISTRY (2008)
Cell-permeable artificial zinc-finger proteins as potent antiviral drugs for human papillomaviruses
Takashi Mino et al.
ARCHIVES OF VIROLOGY (2008)
Enhanced Cleavage of Double-Stranded DNA by Artificial Zinc-Finger Nuclease Sandwiched between Two Zinc-Finger Proteins
Yusuke Mineta et al.
BIOCHEMISTRY (2008)
One- and Two-Metal Ion Catalysis: Global Single-Turnover Kinetic Analysis of the PvuII Endonuclease Mechanism
Fuqian Xie et al.
BIOCHEMISTRY (2008)
CD spectra show the relational style between Zic-, Gli-, Glis-zinc finger protein and DNA
Kumiko Sakai-Kato et al.
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS (2008)
Targeting DNA with triplex-forming oligonucleotides to modify gene sequence
Philippe Simon et al.
BIOCHIMIE (2008)
DNA binding, cleavage, and cytotoxic activity of the preorganized dinuclear zinc(II) complex of triazacyclononane derivatives
Xin Sheng et al.
BIOCONJUGATE CHEMISTRY (2008)
Context-dependent DNA recognition code for C2H2 zinc-finger transcription factors
Jiajian Liu et al.
BIOINFORMATICS (2008)
Zn2+ complexes of di- and tri-nucleating azacrown ligands as base-moiety-selective cleaving agents of RNA 3′,5′-phosphodiester bonds:: Binding to guanine base
Qi Wang et al.
CHEMBIOCHEM (2008)
Embryonic stem cells: The mouse source - Vehicle for mammalian genetics and beyond (Nobel lecture)
Martin Evans
CHEMBIOCHEM (2008)
Addressing the numbers problem in directed evolution
Manfred T. Reetz et al.
CHEMBIOCHEM (2008)
Molecular design of specific metal-binding peptide sequences from protein fragments: Theory and experiment
Milan Kozisek et al.
CHEMISTRY-A EUROPEAN JOURNAL (2008)
New redesigned zinc-finger proteins: Design strategy and its application
Shigeru Negi et al.
CHEMISTRY-A EUROPEAN JOURNAL (2008)
Roles of metal ions in nucleases
Cynthia M. Dupureur
CURRENT OPINION IN CHEMICAL BIOLOGY (2008)
Approaching the minimal metal ion binding peptide for structural and functional metalloenzyme mimicking
Ida Noemi Jakab et al.
DALTON TRANSACTIONS (2008)
Progress and prospects: Zinc-finger nucleases as gene therapy agents
D. Carroll
GENE THERAPY (2008)
DNA double-strand break processing: the beginning of the end
Steven Raynard et al.
GENES & DEVELOPMENT (2008)
Efficient ends-out gene targeting in Drosophila
Juan Huang et al.
GENETICS (2008)
Targeted gene knock in and sequence modulation mediated by a psoralen-linked triplex-forming oligonucleotide
Alokes Majumdar et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Fixing DNA breaks during class switch recombination
Christopher J. Jolly et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2008)
Copper(II), nickel(II) and zinc(II) complexes of N-acetyl-His-Pro-His-His-NH2:: Equilibria, solution structure and enzyme mimicking
Noemi I. Jakab et al.
JOURNAL OF INORGANIC BIOCHEMISTRY (2008)
Physical basis of structural and catalytic Zn-binding sites in proteins
Yu-ming Lee et al.
JOURNAL OF MOLECULAR BIOLOGY (2008)
Targeting abasic sites and single base bulges in DNA with metalloinsertors
Brian M. Zeglis et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2008)
Rapid Open-Source engineering of customized zinc-finger nucleases for highly efficient gene modification
Morgan L. Maeder et al.
MOLECULAR CELL (2008)
Stable and functional lymphoid reconstitution in artemis-deficient mice following lentiviral artemis gene transfer into hematopoietic stem cells
Fatine Benjelloun et al.
MOLECULAR THERAPY (2008)
Comparison of zinc finger nucleases for use in gene targeting in mammalian cells
Shondra M. Pruett-Miller et al.
MOLECULAR THERAPY (2008)
Zinc-finger nucleases: The next generation emerges
Toni Cathomen et al.
MOLECULAR THERAPY (2008)
DNA-binding specificity is a major determinant of the activity and toxicity of zinc-finger Nucleases
Tatjana I. Cornu et al.
MOLECULAR THERAPY (2008)
Molecular basis of xeroderma pigmentosum group C DNA recognition by engineered meganucleases
Pilar Redondo et al.
NATURE (2008)
Establishment of HIV-1 resistance in CD4+ T cells by genome editing using zinc-finger nucleases
Elena E. Perez et al.
NATURE BIOTECHNOLOGY (2008)
Heritable targeted gene disruption in zebrafish using designed zinc-finger nucleases
Yannick Doyon et al.
NATURE BIOTECHNOLOGY (2008)
Targeted gene inactivation in zebrafish using engineered zinc-finger nucleases
Xiangdong Meng et al.
NATURE BIOTECHNOLOGY (2008)
Fish fingers on the menu
Veronique Kiermer
NATURE METHODS (2008)
Unexpected failure rates for modular assembly of engineered zinc fingers
Cherie L. Ramirez et al.
NATURE METHODS (2008)
Artificial restriction DNA cutter for site-selective scission of double-stranded DNA with tunable scission site and specificity
Makoto Komiyama et al.
NATURE PROTOCOLS (2008)
Finding a match: how do homologous sequences get together for recombination?
Adi Barzel et al.
NATURE REVIEWS GENETICS (2008)
Recognition of a common rDNA target site in archaea and eukarya by analogous LAGLIDADG and His-Cys box homing endonucleases
Norimichi Nomura et al.
NUCLEIC ACIDS RESEARCH (2008)
DBD-Hunter: a knowledge-based method for the prediction of DNA-protein interactions
Mu Gao et al.
NUCLEIC ACIDS RESEARCH (2008)
Chiral introduction of positive charges to PNA for double-duplex invasion to versatile sequences
Takumi Ishizuka et al.
NUCLEIC ACIDS RESEARCH (2008)
Dynamics and consequences of DNA looping by the FokI restriction endonuclease
Lucy E. Catto et al.
NUCLEIC ACIDS RESEARCH (2008)
Computer design of obligate heterodimer meganucleases allows efficient cutting of custom DNA sequences
Emmanuel Fajardo-Sanchez et al.
NUCLEIC ACIDS RESEARCH (2008)
Crystal structures of I-SceI complexed to nicked DNA substrates: snapshots of intermediates along the DNA cleavage reaction pathway
Carmen M. Moure et al.
NUCLEIC ACIDS RESEARCH (2008)
How PspGI, catalytic domain of EcoRII and Ecl18kI acquire specificities for different DNA targets
Gintautas Tamulaitis et al.
NUCLEIC ACIDS RESEARCH (2008)
Development of a single-chain, quasi-dimeric zinc-finger nuclease for the selective degradation of mutated human mitochondrial DNA
Michal Minczuk et al.
NUCLEIC ACIDS RESEARCH (2008)
Structural and evolutionary classification of Type II restriction enzymes based on theoretical and experimental analyses
Jerzy Orlowski et al.
NUCLEIC ACIDS RESEARCH (2008)
PNA based artificial nucleases displaying catalysis with turnover in the cleavage of a leukemia related RNA model
Merita Murtola et al.
ORGANIC & BIOMOLECULAR CHEMISTRY (2008)
Prompt site-selective DNA hydrolysis by Ce(IV)-EDTA using oligonucleotide multiphosphonate conjugates
Tuomas Lonnberg et al.
ORGANIC & BIOMOLECULAR CHEMISTRY (2008)
Crystal structure of I-Dmol in complex with its target DNA provides new insights into meganuclease engineering
Maria Jose Marciada et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Increasing cloning possibilities using artificial zinc finger nucleases
Vardit Zeevi et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Targeted gene knockout in mammalian cells by using engineered zinc-finger nucleases
Yolanda Santiago et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Evolution of sequence specificity in a restriction endonuclease by a point mutation
Matheshwaran Saravanan et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Efficient gene targeting in Drosophila by direct embryo injection with zinc-finger nucleases
Kelly J. Beumer et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Light-activated DNA binding in a designed allosteric protein
Devin Strickland et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Structures of the rare-cutting restriction endonuclease NotI reveal a unique metal binding fold involved in DNA binding
Abigail R. Lambert et al.
STRUCTURE (2008)
Tools to study DNA repair: what's in the box?
Sascha Feuerhahn et al.
TRENDS IN GENETICS (2008)
Structural and biophysical analysis of the DNA binding properties of myelin transcription factor 1
Roland Gamsjaeger et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Generation and analysis of mesophilic variants of the thermostable archaeal I-DmoI homing endonuclease
Jesus Prieto et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
The mechanism of human nonhomologous DNA end joining
Michael R. Lieber
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
The Pfam protein families database
Robert D. Finn et al.
NUCLEIC ACIDS RESEARCH (2008)
Regulation of DNA double-strand break repair pathway choice
Meena Shrivastav et al.
CELL RESEARCH (2008)
Flexibility in the order of action and in the enzymology of the nuclease, polymerases, and ligase of vertebrate nonhomologous DNA end joining: relevance to cancer, aging, and the immune system
Michael R. Lieber et al.
CELL RESEARCH (2008)
Probing the two-metal ion mechanism in the restriction endonuclease BamHI
Letif Mones et al.
BIOCHEMISTRY (2007)
Thermodynamics of DNA target site recognition by homing endonucleases
Jennifer H. Eastberg et al.
NUCLEIC ACIDS RESEARCH (2007)
Targeted genome modifications using integrase-deficient lentiviral vectors
Tatjana I. Cornu et al.
MOLECULAR THERAPY (2007)
DNA strand cleavage near a CC mismatch directed by a metalloinsertor
Mi Hee Lim et al.
INORGANIC CHEMISTRY (2007)
Dual role for Zn2+ in maintaining structural integrity and inducing DNA sequence specificity in a promiscuous endonuclease
Matheshwaran Saravanan et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Custom-designed zinc finger nucleases: What is next?
J. Wu et al.
CELLULAR AND MOLECULAR LIFE SCIENCES (2007)
Gene editing in human stem cells using zinc finger nucleases and integrase-defective lentiviral vector delivery
Angelo Lombardo et al.
NATURE BIOTECHNOLOGY (2007)
Coevolution of a homing endonuclease and its host target sequence
Michelle Scalley-Kim et al.
JOURNAL OF MOLECULAR BIOLOGY (2007)
Rational design of a chimeric endonuclease targeted to NotI recognition site
Penghua Zhang et al.
PROTEIN ENGINEERING DESIGN & SELECTION (2007)
Homing endonuclease mediated gene targeting in Anopheles gambiae cells and embryos
Nikolai Windbichler et al.
NUCLEIC ACIDS RESEARCH (2007)
Engineered I-Crel derivatives cleaving sequences from the human XPC gene can induce highly efficient gene correction in mammalian cells
Sylvain Arnould et al.
JOURNAL OF MOLECULAR BIOLOGY (2007)
Recognition of polyadenosine RNA by zinc finger proteins
Seth M. Kelly et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
α-helical linker of an artificial 6-zinc finger peptide contributes to selective DNA binding to a discontinuous recognition sequence
Wei Yan et al.
BIOCHEMISTRY (2007)
Influence of stereochemistry and redox potentials on the single- and double-strand DNA cleavage efficiency of Cu(II)• and Ni(II)•Lys-Gly-His-derived ATCUN metallopeptides
Yan Jin et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2007)
Structure-based redesign of the dimerization interface reduces the toxicity of zinc-finger nucleases
Michal Szczepek et al.
NATURE BIOTECHNOLOGY (2007)
Zinc Finger Targeter (ZiFiT): An engineered zinc finger/target site design tool
Jeffry D. Sander et al.
NUCLEIC ACIDS RESEARCH (2007)
An improved zinc-finger nuclease architecture for highly specific genome editing
Jeffrey C. Miller et al.
NATURE BIOTECHNOLOGY (2007)
Identification of a single HNH active site in type IIS restriction endonuclease Eco31I
Arturas Jakubauskas et al.
JOURNAL OF MOLECULAR BIOLOGY (2007)
DNA-Binding ability of GAGA zinc finger depends on the nature of amino acids present in the β-hairpin
Muthu Dhanasekaran et al.
BIOCHEMISTRY (2007)
Mutability of an HNH nuclease imidazole general base and exchange of a deprotonation mechanism
Jennifer H. Eastberg et al.
BIOCHEMISTRY (2007)
Zorro locked nucleic acid induces sequence-specific gene silencing
Rongbin Ge et al.
FASEB JOURNAL (2007)
Gene therapy for severe combined immunodeficiency: are we there yet?
Marina Cavazzana-Calvo et al.
JOURNAL OF CLINICAL INVESTIGATION (2007)
The conserved asparagine in the HNH motif serves an important structural role in metal finger endonucleases
Hsinchin Huang et al.
JOURNAL OF MOLECULAR BIOLOGY (2007)
The restriction fold turns to the dark side: a bacterial homing endonuclease with a PD-(D/E)-XK motif
Lei Zhao et al.
EMBO JOURNAL (2007)
The C-terminal loop of the homing endonuclease I-CreI is essential for site recognition, DNA binding and cleavage
Jesus Prieto et al.
NUCLEIC ACIDS RESEARCH (2007)
An EcoRI-RsrI chimeric restriction endonuclease retains parental sequence specificity
Tungalag Chuluunbaatar et al.
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS (2007)
Repair and recombination induced by triple helix DNA
Joanna Y. Chin et al.
FRONTIERS IN BIOSCIENCE-LANDMARK (2007)
Topology of type II REases revisited;: structural classes and the common conserved core
Masha Y. Niv et al.
NUCLEIC ACIDS RESEARCH (2007)
Chemical modification of Ce(IV)/EDTA-based artificial restriction DNA cutter for versatile manipulation of double-stranded DNA
Yoji Yamamoto et al.
NUCLEIC ACIDS RESEARCH (2007)
I-Ssp6803I: the first homing endonuclease from the PD-(D/E)XK superfamily exhibits an unusual mode of DNA recognition
Jerzy Orlowski et al.
BIOINFORMATICS (2007)
C2H2 zinc finger-SET histone methyltransferase is a plant-specific chromatin modifier
Alexander Krichevsky et al.
DEVELOPMENTAL BIOLOGY (2007)
Targeted gene addition into a specified location in the human genome using designed zinc finger nucleases
E. A. Moehle et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Structure-based prediction of C2H2 zinc-finger binding specificity:: sensitivity to docking geometry
Trevor W. Siggers et al.
NUCLEIC ACIDS RESEARCH (2007)
Meganucleases and DNA double-strand break-induced recombination:: Perspectives for gene therapy
Frederic Paques et al.
CURRENT GENE THERAPY (2007)
An allosteric-feedback mechanism for protein-assisted group I intron splicing
Mark G. Caprara et al.
RNA (2007)
A novel endonuclease activity associated with the Arabidopsis ortholog of the 30-kDa subunit of cleavage and polyadenylation specificity factor
Balasubrahmanyam Addepalli et al.
NUCLEIC ACIDS RESEARCH (2007)
Development of artificial restriction DNA cutter composed of Ce(IV)/EDTA and PNA
Yoji Yamamoto et al.
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS (2007)
Restriction endonucleases that resemble a component of the bacterial DNA repair machinery
M. Sokolowska et al.
CELLULAR AND MOLECULAR LIFE SCIENCES (2007)
DNA base mismatch detection with bulky rhodium intercalators: synthesis and applications
Brian M. Zeglis et al.
NATURE PROTOCOLS (2007)
Mimicking enzymes: Cooperation between organic functional groups and metal ions in the cleavage of phosphate diesters
Monica Livieri et al.
CHEMISTRY-A EUROPEAN JOURNAL (2007)
REBASE - enzymes and genes for DNA restriction and modification
Richard J. Roberts et al.
NUCLEIC ACIDS RESEARCH (2007)
Metallo-intercalators and metallo-insertors
Brian M. Zeglis et al.
CHEMICAL COMMUNICATIONS (2007)
Direct monitoring of formation and dissociation of individual metal complexes by single-molecule fluorescence spectroscopy
Alexander Kiel et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2007)
Resolving RAD51C function in late stages of homologous recombination
Shyam K. Sharan et al.
CELL DIVISION (2007)
Metal-binding sites at the active site of restriction endonuclease BamHI can conform to a one-ion mechanism
Letif Mones et al.
BIOLOGICAL CHEMISTRY (2007)
Sequence-specific modification of mitochondrial DNA using a chimeric zinc finger methylase
Michal Minczuk et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Of folding and function: Understanding active-site context through metalloenzyme design
Kinesha L. Harris et al.
INORGANIC CHEMISTRY (2006)
A combinatorial approach to create artificial homing endonucleases cleaving chosen sequences
Julianne Smith et al.
NUCLEIC ACIDS RESEARCH (2006)
Targeted chromosomal gene modification in human cells by single-stranded oligodeoxynucleotides in the presence of a DNA double-strand break
Frank Radecke et al.
MOLECULAR THERAPY (2006)
Transcriptional regulation by competing transcription factor modules
Rutger Hermsen et al.
PLOS COMPUTATIONAL BIOLOGY (2006)
Identification of a new subfamily of HNH nucleases and experimental characterization of a representative member, HphI restriction endonuclease
Iwona A. Cymerman et al.
PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS (2006)
Generation of a mouse mutant by oligonucleotide-mediated gene modification in ES cells
Marieke Aarts et al.
NUCLEIC ACIDS RESEARCH (2006)
Solution structures and characterization of human immunodeficiency virus Rev responsive element IIB RNA targeting zinc finger proteins
Subrata H. Mishra et al.
BIOPOLYMERS (2006)
Employing libraries of zinc finger artificial transcription factors to screen for homologous recombination mutants in Arabidopsis
Beatrice I. Lindhout et al.
PLANT JOURNAL (2006)
Induction and repair of zinc-finger nuclease-targeted double-strand breaks in Caenorhabditis elegans somatic cells
Jason Morton et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Structure of Aart, a designed six-finger zinc finger peptide, bound to DNA
David J. Segal et al.
JOURNAL OF MOLECULAR BIOLOGY (2006)
DNA mismatch-specific targeting and hypersensitivity of mismatch-repair-deficient cells to bulky rhodium(III) intercalators
Jonathan R. Hart et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Mis-translation of a computationally designed protein yields an exceptionally stable homodimer: Implications for protein engineering and evolution
Gautam Dantas et al.
JOURNAL OF MOLECULAR BIOLOGY (2006)
Mechanism of homologous recombination: mediators and helicases take on regulatory functions
Patrick Sung et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2006)
Homing endonuclease I-CreI derivatives with novel DNA target specificities
Laura E. Rosen et al.
NUCLEIC ACIDS RESEARCH (2006)
Positively charged C-terminal subdomains of EcoRV endonuclease: Contributions to DNA binding, bending, and cleavage
David A. Hiller et al.
BIOCHEMISTRY (2006)
Engineered lanthanide-binding metallohomeodomains: Designing folded chimeras by modular turn substitution
Sunghyuk Lim et al.
PROTEIN SCIENCE (2006)
Targeting chromosomal sites with locked nucleic acid-modified triplex-forming oligonucleotides: study of efficiency dependence on DNA nuclear environment
Erika Brunet et al.
NUCLEIC ACIDS RESEARCH (2006)
The crystal structure of the rare-cutting restriction enzyme Sdal reveals unexpected domain architecture
Giedre Tamulaitiene et al.
STRUCTURE (2006)
From monomeric to homodimeric endonucleases and back: Engineering novel specificity of LAGLIDADG enzymes
George H. Silva et al.
JOURNAL OF MOLECULAR BIOLOGY (2006)
Computational design of a new hydrogen bond network and at least a 300-fold specificity switch at a protein-protein interface
Lukasz A. Joachimiak et al.
JOURNAL OF MOLECULAR BIOLOGY (2006)
Tension-dependent DNA cleavage by restriction endonucleases: Two-site enzymes are switched off at low force
Gregory J. Gemmen et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Targeted gene repair: The ups and downs of a promising gene therapy approach
David de Semir et al.
CURRENT GENE THERAPY (2006)
Human SMC5/6 complex promotes sister chromatid homologous recombination by recruiting the SMC1/3 cohesin complex to double-strand breaks
Patrick Ryan Potts et al.
EMBO JOURNAL (2006)
In vitro selection of zinc finger DNA-binding proteins through ribosome display
Hiroshi Ihara et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2006)
Zinc finger tools: custom DNA-binding domains for transcription factors and nucleases
Jeffrey G. Mandell et al.
NUCLEIC ACIDS RESEARCH (2006)
3D-QSAR study for DNA cleavage proteins with a potential anti-tumor ATCUN-like motif
Humberto Gonzalez-Diaz et al.
JOURNAL OF INORGANIC BIOCHEMISTRY (2006)
Computational redesign of endonuclease DNA binding and cleavage specificity
Justin Ashworth et al.
NATURE (2006)
Involvement of the Arabidopsis SWI2/SNF2 chromatin remodeling gene family in DNA damage response and recombination
Hezi Shaked et al.
GENETICS (2006)
Site-specific DNA photocleavage by rhodium intercalators analyzed by MALDI-TOF mass spectrometry
Jens Brunner et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2006)
Zn2+ dependent DNA binders based on terminally modified peptide nucleic acids
I Boll et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2006)
I-Basl and I-Hmul: Two phage intron-encoded endonucleases with homologous DNA recognition sequences but distinct DNA Specificities
Markus Landthaler et al.
JOURNAL OF MOLECULAR BIOLOGY (2006)
Cellular uptake of PNA -: Terpyridine conjugates and its enhancement by Zn2+ ions
Andreas Fuessl et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2006)
The structure of I-Ceul homing endonuclease: Evolving asymmetric DNA recognition from a symmetric protein scaffold
P. Clint Spiegel et al.
STRUCTURE (2006)
Efficient in toto targeted recombination in mouse liver by meganuclease-induced double-strand break
Agnes Gouble et al.
JOURNAL OF GENE MEDICINE (2006)
Making and breaking nucleic acids:: Two-Mg2+-ion catalysis and substrate specificity
W Yang et al.
MOLECULAR CELL (2006)
Chemical-reaction-based site-selective DNA cutter for PCR-free gene manipulation
Y Yamamoto et al.
CHEMBIOCHEM (2006)
Efficient gene targeting in Drosophila with zinc-finger nucleases
K Beumer et al.
GENETICS (2006)
Effective oligonucleotide-mediated gene disruption in ES cells lacking the mismatch repair protein MSH3
M Dekker et al.
GENE THERAPY (2006)
Exploring the recognition of quadruplex DNA by an engineered Cys2-His2 zinc finger protein
S Ladame et al.
BIOCHEMISTRY (2006)
Mammalian gene targeting with designed zinc finger nucleases
MH Porteus
MOLECULAR THERAPY (2006)
Crystal structural analysis and metal-dependent stability and activity studies of the ColE7 endonuclease domain in complex with DNA/Zn2+ or inhibitor/Ni2+
LG Doudeva et al.
PROTEIN SCIENCE (2006)
Design and evolution of new catalytic activity with an existing protein scaffold
HS Park et al.
SCIENCE (2006)
Engineering of large numbers of highly specific homing endonucleases that induce recombination on novel DNA targets
S Arnould et al.
JOURNAL OF MOLECULAR BIOLOGY (2006)
Designer zinc-finger proteins and their applications
M Papworth et al.
GENE (2006)
Standardized reagents and protocols for engineering zinc finger nucleases by modular assembly
David A. Wright et al.
NATURE PROTOCOLS (2006)
Design, construction and in vitro testing of zinc finger nucleases
Dana Carroll et al.
NATURE PROTOCOLS (2006)
Affinity selection of DNA-binding protein complexes using mRNA display
S Tateyama et al.
NUCLEIC ACIDS RESEARCH (2006)
MSH2 is essential for the preservation of genome integrity and prevents homeologous recombination in the moss Physcomitrella patens
B Trouiller et al.
NUCLEIC ACIDS RESEARCH (2006)
DNA looping by two-site restriction endonucleases: heterogeneous probability size and unbinding force
Gregory J. Gemmen et al.
NUCLEIC ACIDS RESEARCH (2006)
Enzymatic amplification in a bioinspired, autonomous signal cascade
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CHEMICAL COMMUNICATIONS (2006)
Molecular basis of the targeting of topoisomerase II-mediated DNA cleavage by VP16 derivatives conjugated to triplex-forming oligonucleotides
M Duca et al.
NUCLEIC ACIDS RESEARCH (2006)
Metal complex catalysis on a double stranded DNA template
Iris Boll et al.
CHEMICAL COMMUNICATIONS (2006)
Protein assembly and DNA looping by the FokI restriction endonuclease
LE Catto et al.
NUCLEIC ACIDS RESEARCH (2006)
A metal-ion-releasing probe for DNA detection by catalytic signal amplification
Nora Graf et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2006)
Sequence preference in DNA binding: de novo designed helix-turn-helix metallopeptides recognize a family of DNA target sites
SW Wong-Deyrup et al.
JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY (2006)
Recombination of the GFP gene to the BFP gene using a man-made site-selective DNA cutter
Y Kitamura et al.
JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY (2006)
Designer zinc finger proteins: Tools for creating artificial DNA-binding functional proteins
M Dhanasekaran et al.
ACCOUNTS OF CHEMICAL RESEARCH (2006)
A look to future directions in gene therapy research for monogenic diseases
Matthew H. Porteus et al.
PLOS GENETICS (2006)
The role of AtMSH2 in homologous recombination in Arabidopsis thaliana
E Emmanuel et al.
EMBO REPORTS (2006)
Allosteric control of oligonucleotide hybridization by metal-induced cyclization
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JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2005)
Non-cognate Enzyme-DNA complex: Structural and kinetic analysis of EcoRV endonuclease bound to the EcoRl recognition site GAATTC
DA Hiller et al.
JOURNAL OF MOLECULAR BIOLOGY (2005)
High-frequency homologous recombination in plants mediated by zinc-finger nucleases
DA Wright et al.
PLANT JOURNAL (2005)
Development of zinc finger domains for recognition of the 5′-CNN-3′ family DNA sequences and their use in the construction of artificial transcription factors
B Dreier et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Custom zinc-finger nucleases for use in human cells
S Alwin et al.
MOLECULAR THERAPY (2005)
Site-selective DNA hydrolysis by CeIV-EDTA with the use of one oligonucleotide additive bearing two monophosphates
W Chen et al.
CHEMBIOCHEM (2005)
Binding of two zinc finger nuclease monomers to two specific sites is required for effective double-strand DNA cleavage
M Mani et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2005)
Evolution from DNA to RNA recognition by the bI3 LAGLIDADG maturase
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NATURE STRUCTURAL & MOLECULAR BIOLOGY (2005)
MnlI - The member of H-N-H subtype of Type IIS restriction endonucleases
E Kriukiene et al.
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS (2005)
Gene targeting using zinc finger nucleases
MH Porteus et al.
NATURE BIOTECHNOLOGY (2005)
Structural insights into the mechanism of Nuclease A, a ββα metal nuclease from Anabaena
M Ghosh et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Highly efficient endogenous human gene correction using designed zinc-finger nucleases
FD Urnov et al.
NATURE (2005)
Structural insights into the first incision reaction during nucleotide excision repair
JJ Truglio et al.
EMBO JOURNAL (2005)
Type II restriction endonucleases: structure and mechanism
A Pingoud et al.
CELLULAR AND MOLECULAR LIFE SCIENCES (2005)
Swapping of the β-hairpin region between sp1 and GLI zinc fingers:: Significant role of the β-hairpin region in DNA binding properties of C2H2-type zinc finger peptides
Y Shiraishi et al.
BIOCHEMISTRY (2005)
Targeted mutagenesis using zinc-finger nucleases in Arabidopsis
A Lloyd et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Hybridization dependent cleavage of internally modified disulfide-peptide nucleic acids
I Boll et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2005)
Homing endonuclease structure and function
BL Stoddard
QUARTERLY REVIEWS OF BIOPHYSICS (2005)
Structural and functional insight into sugar-nonspecific nucleases in host defense
KC Hsia et al.
CURRENT OPINION IN STRUCTURAL BIOLOGY (2005)
Zinc finger nucleases: custom-designed molecular scissors for genome engineering of plant and mammalian cells
S Durai et al.
NUCLEIC ACIDS RESEARCH (2005)
Developing a programmed restriction endonuclease for highly specific DNA cleavage
K Eisenschmidt et al.
NUCLEIC ACIDS RESEARCH (2005)
In vivo selection of engineered homing endonucleases using double-strand break induced homologous recombination
P Chames et al.
NUCLEIC ACIDS RESEARCH (2005)
On/off regulation of catalysis by allosteric control of metal complex nuclearity
L Kovbasyuk et al.
CHEMICAL COMMUNICATIONS (2004)
Chimeras of the homing endonuclease PI-Scel and the homologous Candida tropicalis Intein:: A study to explore the possibility of exchanging DNA-binding modules to obtain highly specific endonucleases with altered specificity
S Steuer et al.
CHEMBIOCHEM (2004)
The design of functional DNA-binding proteins based on zinc finger domains
D Jantz et al.
CHEMICAL REVIEWS (2004)
Zinc-nucleic acid interaction
S Aoki et al.
CHEMICAL REVIEWS (2004)
DNA binding and cleavage by the HNH homing endonuclease I-Hmul
BW Shen et al.
JOURNAL OF MOLECULAR BIOLOGY (2004)
Isolation and characterization of new homing endonuclease specificities at individual target site positions
D Sussman et al.
JOURNAL OF MOLECULAR BIOLOGY (2004)
Promoter-targeted phage display selections with preassembled synthetic zinc finger libraries for endogenous gene regulation
CV Lund et al.
JOURNAL OF MOLECULAR BIOLOGY (2004)
Metal-dependent DNA cleavage mechanism of the I-CreI LAGLIDADG homing endonuclease
B Chevalier et al.
BIOCHEMISTRY (2004)
Translation of hepatitis B virus (HBV) surface proteins from the HBV pregenome and precore RNAs in Semliki Forest virus-driven expression
A Zajakina et al.
JOURNAL OF GENERAL VIROLOGY (2004)
Allosteric supramolecular receptors and catalysts
L Kovbasyuk et al.
CHEMICAL REVIEWS (2004)
Zn2+-dependent peptide nucleic acids probes
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JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2004)
Assessing the plasticity of DNA target site recognition of the Pl-Scel homing endonuclease using a bacterial two-hybrid selection system
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JOURNAL OF MOLECULAR BIOLOGY (2003)
The crystal structure of the gene targeting homing endonuclease I-SceI reveals the origins of its target site specificity
CM Moure et al.
JOURNAL OF MOLECULAR BIOLOGY (2003)
Structural and biochemical analyses of DNA and RNA binding by a bifunctional homing endonuclease and group I intron splicing factor
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GENES & DEVELOPMENT (2003)
Design of a novel globular protein fold with atomic-level accuracy
B Kuhlman et al.
SCIENCE (2003)
Highly specific zinc finger proteins obtained by directed domain shuffling and cell-based selection
JA Hurt et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
Constraints for zinc finger linker design as inferred from X-ray crystal structure of tandem Zif268-DNA complexes
E Peisach et al.
JOURNAL OF MOLECULAR BIOLOGY (2003)
Flexible DNA target site recognition by divergent homing endonuclease isoschizomers I-CreI and I-MsoI
B Chevalier et al.
JOURNAL OF MOLECULAR BIOLOGY (2003)
Enhancing gene targeting with designed zinc finger nucleases
M Bibikova et al.
SCIENCE (2003)
Chimeric nucleases stimulate gene targeting in human cells
MH Porteus et al.
SCIENCE (2003)
Efficient gene targeting mediated by adeno-associated virus and DNA double-strand breaks
MH Porteus et al.
MOLECULAR AND CELLULAR BIOLOGY (2003)
Metal ions and phosphate binding in the H-N-H motif: Crystal structures of the nuclease domain of ColE7/Im7 in complex with a phosphate ion and different divalent metal ions
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PROTEIN SCIENCE (2002)
Catalytic mechanisms of restriction and homing endonucleases
EA Galburt et al.
BIOCHEMISTRY (2002)
Crystal structure of the intein homing endonuclease PI-SceI bound to its recognition sequence
CM Moure et al.
NATURE STRUCTURAL BIOLOGY (2002)
Design, activity, and structure of a highly specific artificial endonuclease
BS Chevalier et al.
MOLECULAR CELL (2002)
High resolution crystal structure of domain I of the Saccharomyces cerevisiae homing endonuclease PI-SceI
E Werner et al.
NUCLEIC ACIDS RESEARCH (2002)
Validated zinc finger protein designs for all 16 GNN DNA triplet targets
Q Liu et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Custom DNA-binding proteins come of age: polydactyl zinc-finger proteins
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CURRENT OPINION IN BIOTECHNOLOGY (2001)
Exploring the DNA-binding specificities of zinc fingers with DNA microarrays
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
HIV Rev peptides conjugated with peptide nucleic acids and their efficient binding to RRE RNA
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BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2001)
Making the most of metal ions
NC Horton et al.
NATURE STRUCTURAL BIOLOGY (2001)
The homing endonuclease I-CreI uses three metals, one of which ss shared between the two active sites
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NATURE STRUCTURAL BIOLOGY (2001)
Stimulation of homologous recombination through targeted cleavage by chimeric nucleases
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MOLECULAR AND CELLULAR BIOLOGY (2001)
Crystal structure of an archaeal intein-encoded homing endonuclease PI-PfuI
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