Journal
FUTURE MEDICINAL CHEMISTRY
Volume 2, Issue 4, Pages 619-646Publisher
FUTURE SCI LTD
DOI: 10.4155/FMC.09.172
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Funding
- National Institutes of Health [1S10RR16659, CA122952]
- NATIONAL CANCER INSTITUTE [R01CA122952] Funding Source: NIH RePORTER
- NATIONAL CENTER FOR RESEARCH RESOURCES [S10RR016659] Funding Source: NIH RePORTER
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DNA G-quadruplexes are DNA secondary structures formed in specific G-rich sequences. DNA sequences that can form G-quadruplexes have been found in regions with biological significance, such as human telomeres and oncogene-promoter regions. DNA G-quadruplexes have recently emerged as a new class of novel molecular targets for anticancer drugs. Recent progress on structural studies of the biologically relevant G-quadruplexes formed in human telomeres and in the promoter regions of human oncogenes will be discussed, as well as recent advances in the design and development of G-quadruplex-interactive drugs. DNA G-quadruplexes can readily form in solution under physiological conditions and are globularly folded nucleic acid structures. The molecular structures of intramolecular G-quadruplexes appear to differ from one another and, therefore, in principle may be differentially regulated and targeted by different proteins and drugs.
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