Related references
Note: Only part of the references are listed.An Environmental DNA-Derived Type II Polyketide Biosynthetic Pathway Encodes the Biosynthesis of the Pentacyclic Polyketide Erdacin
Ryan W. King et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2009)
The Biosynthetic Logic of Polyketide Diversity
Christian Hertweck
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2009)
Mammalian target of rapamycin inhibitors and their potential role in therapy in leukaemia and other haematological malignancies
David T. Teachey et al.
BRITISH JOURNAL OF HAEMATOLOGY (2009)
Targeting mTOR with rapamycin One dose does not fit all
David A. Foster et al.
CELL CYCLE (2009)
Impact of Natural Products on Developing New Anti-Cancer Agents
Gordon M. Cragg et al.
CHEMICAL REVIEWS (2009)
Discovery of Innovative Small Molecule Therapeutics
Magid Abou-Gharbia
JOURNAL OF MEDICINAL CHEMISTRY (2009)
Recent advances in the chemistry, biosynthesis and pharmacology of rapamycin analogs
Edmund I. Graziani
NATURAL PRODUCT REPORTS (2009)
Metabolites from symbiotic bacteria
Joern Piel
NATURAL PRODUCT REPORTS (2009)
Decoding and engineering tetracycline biosynthesis
Lauren B. Pickens et al.
METABOLIC ENGINEERING (2009)
Cultivation-independent approaches to investigate the chemistry of marine symbiotic bacteria
Agustinus Uria et al.
PHYTOCHEMISTRY REVIEWS (2009)
Triggering cryptic natural product biosynthesis in microorganisms
Kirstin Scherlach et al.
ORGANIC & BIOMOLECULAR CHEMISTRY (2009)
Epothilones as lead structures for the synthesis-based discovery of new chemotypes for microtubule stabilization
Fabian Feyen et al.
ACCOUNTS OF CHEMICAL RESEARCH (2008)
Catalytic site-selective synthesis and evaluation of a series of erythromycin analogs
Chad A. Lewis et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2008)
Tigecycline for the treatment of multidrug-resistant Enterobacteriaceae: a systematic review of the evidence from microbiological and clinical studies
Theodoros Kelesidis et al.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2008)
Tigecycline for the treatment of patients with severe sepsis or septic shock:: a drug use evaluation in a surgical intensive care unit
Stefanie Swoboda et al.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2008)
(3R,5S,E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(methyl(1-methyl-1H-1,2,4-triazo1-5-yl)amino)pyrimidin-5-yl)-3,5-dihydroxyhept-6-enoic acid (BMS-644950):: A rationally designed orally efficacious 3-hydroxy-3-methylglutaryl coenzyme-A reductase inhibitor with reduced myotoxicity potential
Saleem Ahmad et al.
JOURNAL OF MEDICINAL CHEMISTRY (2008)
Natural products as leads to potential drugs: An old process or the new hope for drug discovery?
David J. Newman
JOURNAL OF MEDICINAL CHEMISTRY (2008)
A Robust Platform for the Synthesis of New Tetracycline Antibiotics
Cuixiang Sun et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2008)
Protein-protein interaction detection in vitro and in cells by proximity biotinylation
Marta Fernandez-Suarez et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2008)
A gift from nature: the birth of the statins
Akira Endo
NATURE MEDICINE (2008)
Therapeutic effect against human xenograft tumors in nude mice by the third generation microtubule stabilizing epothilones
Ting-Chao Chou et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Binding of rapamycin analogs to channels and FKBP52 contributes their neuroprotective activities
Benfang Ruan et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Complete genome sequence of the myxobacterium Sorangium cellulosum
Susanne Schneiker et al.
NATURE BIOTECHNOLOGY (2007)
The immunophilin FKBP52 specifically binds to tubulin and prevents microtubule formation
Beatrice Chambraud et al.
FASEB JOURNAL (2007)
EDP-420, a bicyclolide (bridged bicyclic macrolide), is active against Mycobactetium avium
Luiz E. Bermudez et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2007)
Targeting mammalian target of rapamycin (mTOR) for health and diseases
Chi Kwan Tsang et al.
DRUG DISCOVERY TODAY (2007)
Anticancer drugs from nature - natural products as a unique source of new microtubule-stabilizing agents
Karl-Heinz Altmann et al.
NATURAL PRODUCT REPORTS (2007)
Myxobacterial natural product assembly lines: fascinating examples of curious biochemistry
Silke Christine Wenzel et al.
NATURAL PRODUCT REPORTS (2007)
The chemistry and biology of epothilones - The wheel keeps turning
Karl-Heinz Altmann et al.
CHEMMEDCHEM (2007)
Therapeutic potential of natural product signal transduction agents
Frank E. Koehn
CURRENT OPINION IN BIOTECHNOLOGY (2006)
C-15 thiazol-4-yl analogues of (E)-9,10-didehydroepothilone D:: Synthesis and cytotoxicity
Brian R. Hearn et al.
ORGANIC LETTERS (2006)
An interpretive history of the cholesterol controversy, part V: The discovery of the statins and the end of the controversy
Daniel Steinberg
JOURNAL OF LIPID RESEARCH (2006)
Total synthesis and antitumor activity of ZK-EPO: The first fully synthetic epothilone in clinical development
Ulrich Klar et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2006)
Total synthesis of selected bioactive natural products: Illustration of strategy and design
K Tatsuta et al.
CHEMICAL REVIEWS (2005)
The bacterial ribosome as a target for antibiotics
J Poehlsgaard et al.
NATURE REVIEWS MICROBIOLOGY (2005)
Metagenomic analysis reveals diverse polyketide synthase gene clusters in microorganisms associated with the marine sponge Discodermia dissoluta
A Schirmer et al.
APPLIED AND ENVIRONMENTAL MICROBIOLOGY (2005)
Second-generation epothilones: discovery of fludelone and its extraordinary antitumor properties
YS Cho et al.
DRUGS OF THE FUTURE (2005)
Synthesis of (-)-tetracycline
MG Charest et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2005)
Binding site of the bridged macrolides in the Escherichia coli ribosome
LQ Xiong et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2005)
Synthesis of novel 6,11-O-bridged bicyclic ketolides via a palladium-catalyzed bis-allylation
GQ Wang et al.
ORGANIC LETTERS (2004)
Structural basis for the antibiotic activity of ketolides and azalides
F Schlünzen et al.
STRUCTURE (2003)
Development, validation, and application of PCR primers for detection of tetracycline efflux genes of gram-negative bacteria
RI Aminov et al.
APPLIED AND ENVIRONMENTAL MICROBIOLOGY (2002)
Tetracycline antibiotics: Mode of action, applications, molecular biology, and epidemiology of bacterial resistance
I Chopra et al.
MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS (2001)
The first total synthesis of natural (-)-tetracycline
K Tatsuta et al.
CHEMISTRY LETTERS (2000)
A common pharmacophore for Taxol and the epothilones based on the biological activity of a taxane molecule lacking a C-13 side chain
LF He et al.
BIOCHEMISTRY (2000)
A common pharmacophore for epothilone and taxanes: Molecular basis for drug resistance conferred by tubulin mutations in human cancer cells
P Giannakakou et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)