Mgm1 is required for maintenance of mitochondrial function and virulence in Candida albicans

Mitochondria are dynamic organelles, and their shapes and sizes are regulated by mitochondrial fusion and fission. The proteins essential for mitochondrial fusion in Candida albicans have not been clearly characterized. In this study, Mgm1 was explored for its roles in mitochondrial function, cell cycle, hyphal growth and virulence in this pathogen. The deletion of MGM1 led to mitochondrial fragmentation and mtDNA loss and activated the checkpoint pathway to arrest the cell cycle in G1 phase. Moreover, loss of MGM1 led to defects in hyphal development and attenuation of virulence in a macrophage cell line and a mouse model of disseminated infection. These results reveal that Mgm1 plays an important role in mitochondrial dynamics and function, cell cycle progression, hyphal development and virulence in C. albicans.