Journal
FUNGAL GENETICS AND BIOLOGY
Volume 48, Issue 11, Pages 1027-1033Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.fgb.2011.07.009
Keywords
Iron; Copper; Reductive iron assimilation; Siderophore; Ferrireductase
Categories
Funding
- Austrian Science Foundation [FWF P21643-B11]
- Austrian Science Fund (FWF) [P21643] Funding Source: Austrian Science Fund (FWF)
- Austrian Science Fund (FWF) [P 21643] Funding Source: researchfish
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Aspergillus fumigatus employs two high affinity iron uptake mechanisms, siderophore mediated iron uptake and reductive iron assimilation (RIA). The A. fumigatus genome encodes 15 putative metalloreductases (MR) but the ferrireductases involved in RIA remained elusive so far. Expression of the MR FreB was found to be transcriptionally repressed by iron via SreA, a repressor of iron acquisition during iron sufficiency, indicating a role in iron metabolism. FreB-inactivation by gene deletion was phenotypically largely inconspicuous unless combined with inactivation of the siderophore system, which then decreased growth rate, surface ferrireductase activity and oxidative stress resistance during iron starvation. This study also revealed that loss of copper-independent siderophore-mediated iron uptake increases sensitivity of A. fumigatus to copper starvation due to copper-dependence of RIA. (C) 2011 Elsevier Inc. All rights reserved.
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