Journal
FUNGAL GENETICS AND BIOLOGY
Volume 47, Issue 12, Pages 953-961Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.fgb.2010.08.014
Keywords
Aspergillus oryzae; Kojic acid; Secondary metabolism; Transcriptional profile; DNA microarray
Categories
Funding
- Ministry of Education Culture Sports Science and Technology (MEXT)
- New Energy and Industrial Technology Development Organization (NEDO) of Japan
Ask authors/readers for more resources
Kojic acid is produced in large amounts by Aspergillus oryzae as a secondary metabolite and is widely used in the cosmetic industry Glucose can be converted to kojic acid perhaps by only a few steps but no genes for the conversion have thus far been revealed Using a DNA microarray gene expression profiles under three pairs of conditions significantly affecting kojic acid production were compared All genes were ranked using an Index parameter reflecting both high amounts of transcription and a high induction ratio under producing conditions After disruption of nine candidate genes selected from the top of the list two genes of unknown function were found to be responsible for kojic acid biosynthesis one having an oxidoreductase motif and the other a transporter motif These two genes are closely associated in the genome showing typical characteristics of genes Involved in secondary metabolism (C) 2010 Elsevier Inc All rights reserved
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available