Journal
FUNGAL GENETICS AND BIOLOGY
Volume 46, Issue 2, Pages 183-189Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.fgb.2008.11.001
Keywords
Candida albicans; CaMCA1; Oxidative stress; Death; Energy metabolism; Trehalose
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Funding
- National Natural Science Foundation of China [30630071, 30870105]
- Key Scientific and Technological Program Project Grant of Shanghai [06XD14027]
- Shanghai Rising-Star Program [08QA14001]
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Candida albicans, an opportunistic pathogen, can undergo programmed cell death upon various stimuli, including oxidative stress. in this study, we showed that deletion of CaMCA1, a homologue of Saccharomyces cerevisiae metacaspase YCA1, could both attenuated oxidative stress-induced cell death and caspase activation. Compared to wild-type strain, Camca1 Delta mutant showed higher accumulation of trehalose and transcription of the genes related to trehalose biosynthesis (TPS2 and TPS3) under the condition of oxidative stress. Furthermore, lower intracellular ATP concentration and mitochondrial membrane potential, less endogenous reactive oxygen species (ROS) generation were observed in Camca1 Delta mutant. Our results suggest that CaMCA1 might mediate the sensitiveness to oxidative stress by affecting energy metabolism in C. albicans. (C) 2008 Elsevier Inc. All rights reserved.
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