Journal
FUNDAMENTAL & CLINICAL PHARMACOLOGY
Volume 26, Issue 2, Pages 190-193Publisher
WILEY-BLACKWELL
DOI: 10.1111/j.1472-8206.2011.00928.x
Keywords
cGMP; colitis; KATP; sildenafil
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The involvement of cGMP/KATP pathway in effects of sildenafil on experimental colitis was investigated. Sildenafil significantly attenuated colonic injury markers. These effects were reversed by the addition of glibenclamide or ODQ, indicating the involvement of ATP-sensitive potassium channels (KATP) and cGMP, respectively.
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