Journal
FUNDAMENTAL & CLINICAL PHARMACOLOGY
Volume 22, Issue 3, Pages 265-274Publisher
WILEY
DOI: 10.1111/j.1472-8206.2008.00578.x
Keywords
alzheimer's disease; amyloid hypothesis; dementia; drug therapy
Categories
Ask authors/readers for more resources
Dementia is increasingly being recognized as one of the most important medical problems in the elderly. As most pharmacological research within the field of dementia is focused on Alzheimer's dementia (AD), this review will focus on pharmacological interventions in AD. Most disease-modifying therapies are based on the amyloid hypothesis. In this hypothesis, the pathological accumulation of A beta in the brain leads to oxidative stress, neuronal destruction and finally the clinical syndrome of AD. Following this hypothesis, secondary prevention of AD can be made by: decreasing the production of A beta, stimulation of clearance of A beta formed or prevention of aggregation of A beta into amyloid plaques. First a short overview on current approved therapies for AD is given. The main part of the review will focus on potential disease-modifying therapies for AD that are currently being studied in phase I to phase III trials.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available