Journal
JOURNAL OF TRANSLATIONAL MEDICINE
Volume 13, Issue -, Pages -Publisher
BMC
DOI: 10.1186/s12967-015-0467-3
Keywords
H19; miR-675; IGF2; Oncomirs; Lung cancer; Imprinted cluster
Categories
Funding
- BioCancell Therapeutic
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Since it was first described, the imprinted cluster 11p15.5 has been reported to be deregulated in a variety of pediatric and adult cancers including that of the lung. Both protein coding and non-coding genes functioning as oncogenes or as tumor suppressor genes reside within this cluster. Oncomirs that can function as oncogenes or as tumor suppressors have also been reported. While a complete account of the role played by the 11p15.5 imprinted cluster in lung cancer is beyond the scope of this review, we will focus on the role of the non-coding RNAs processed from the H19-IGF2 loci. A special emphasis will be given to the H19/miR-675 gene locus. Their potential diagnostic and therapeutic use in lung cancer will be described.
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