Journal
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
Volume 13, Issue -, Pages S72-S81Publisher
WILEY
DOI: 10.1111/jth.12961
Keywords
catheters; factor XI; factor XII; medical devices; thrombosis
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Blood-contacting medical devices, such as vascular grafts, stents, heart valves, and catheters, are often used to treat cardiovascular diseases. Thrombus formation is a common cause of failure of these devices. This study (i) examines the interface between devices and blood, (ii) reviews the pathogenesis of clotting on blood-contacting medical devices, (iii) describes contemporary methods to prevent thrombosis on blood-contacting medical devices, (iv) explains why some anticoagulants are better than others for prevention of thrombosis on medical devices, and (v) identifies future directions in biomaterial research for prevention of thrombosis on blood-contacting medical devices.
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