Journal
FRONTIERS IN NEUROENDOCRINOLOGY
Volume 32, Issue 1, Pages 10-24Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.yfrne.2010.07.001
Keywords
Chemokines; Cytokines; Cell migration; Stress; Thermoregulation; Feeding and drinking behaviors; Hypothalamus; Pituitary; Neuroendocrine disorders
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Funding
- INSERM
- CNRS
- Italian Association for Cancer Research (AIRC)
- Regional government of Liguria (Italy)
- Fondation pour la Recherche Medicale, University P. and M. Curie, Ministry of French Education, IFR
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Chemokines are small secreted proteins that chemoattract and activate immune and non-immune cells. Their role in the immune system is well-known, and it has recently been suggested that they may also play a role in the central nervous system (CNS). Indeed, they do not only act as immunoinflammatory mediators in the brain but they also act as potential modulators in neurotransmission. Although we are only beginning to be aware of the implication of chemokines in neuroendocrine functions, this review aims at summarizing what is known in that booming field of research. First we describe the expression of chemokines and their receptors in the CNS with a focus on the hypothalamo-pituitary system. Secondly, we present what is known on some chemokines in the regulation of neuroendocrine functions such as cell migration, stress, thermoregulation, drinking and feeding as well as anterior pituitary functions. We suggest that chemokines provide a fine modulatory tuning system of neuroendocrine regulations. (C) 2010 Elsevier Inc. All rights reserved.
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