Journal
FRONTIERS IN NEUROENDOCRINOLOGY
Volume 32, Issue 2, Pages 137-145Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.yfrne.2011.02.009
Keywords
Mouse; Sexual differentiation; Hypothalamus; Sexual behavior; Brain development; Neurogenesis; Neuron migration; Gonadal steroids; Sexual dimorphism
Categories
Funding
- NIH [R01-MH61376]
- ARRS [P4-0053]
Ask authors/readers for more resources
There is little debate that mammalian sexual differentiation starts from the perspective of two primary sexes that correspond to differential sex chromosomes (X versus Y) that lead to individuals with sex typical characteristics. Sex steroid hormones account for most aspects of brain sexual differentiation, however, a growing literature has raised important questions about the role of sex chromosomal genes separate from sex steroid actions. Several important model animals are being used to address these issues and, in particular, they are taking advantage of molecular genetic approaches using different mouse strains. The current review examines the cooperation of genetic and endocrine influences from the perspective of behavioral and morphological hypothalamic sexual differentiation, first in adults and then in development. In the final analysis, there is an ongoing need to account for the influence of hormones in the context of underlying genetic circumstances and null hormone conditions. (C) 2011 Elsevier Inc. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available