Journal
FRONTIERS IN NEUROENDOCRINOLOGY
Volume 31, Issue 3, Pages 241-258Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.yfrne.2010.05.003
Keywords
GnRH; Astrocytes; Tanycytes; Endothelial cells; Nitric oxide; Prostaglandins; Ovarian cycle; Gonadal steroids; Hypothalamus; Reproduction
Categories
Funding
- Institut National de la Sante et de la Recherche Medicale (Inserm, France) [U837]
- Fondation pour la Recherche Medicale (Equipe FRM)
- l'Agence Nationale de la Recherche (ANR)
- Indo-French Centre for the Promotion of Advanced Research (IFCPAR)
- Universite Lille 2
- imaging Core of IFR114
- IFR114
- IFCPAR
- FRM
- Inserm
- ANR
- Region Nord Pas de Calais
- Centre Regional Hospitalier
- Ministere Delegue a la Recherche et aux Nouvelles Technologies
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As the final common pathway for the central control of gonadotropin secretion, GnRH neurons are subjected to numerous regulatory homeostatic and external factors to achieve levels of fertility appropriate to the organism. The GnRH system thus provides an excellent model in which to investigate the complex relationships between neurosecretion, morphological plasticity and the expression of a physiological function. Throughout the reproductive cycle beginning from postnatal sexual development and the onset of puberty to reproductive senescence, and even within the ovarian cycle itself, all levels of the GnRH system undergo morphological plasticity. This structural plasticity within the GnRH system appears crucial to the timely control of reproductive competence within the individual, and as such must have coordinated actions of multiple signals secreted from glial cells, endothelial cells, and GnRH neurons. Thus, the GnRH system must be viewed as a complete neuro-glial-vascular unit that works in concert to maintain the reproductive axis. (C) 2010 Elsevier Inc. All rights reserved.
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