Journal
FRONTIERS IN BIOSCIENCE-LANDMARK
Volume 18, Issue -, Pages 543-563Publisher
FRONTIERS IN BIOSCIENCE INC
DOI: 10.2741/4119
Keywords
Ovarian cancer; Cancerogenesis; Signaling pathway; BRCA1; BRCA2; TP53; PIK3CA; Review
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Funding
- Military Institute of Medicine (Warsaw, Poland)
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Ovarian cancer is characterized by the highest mortality rate among gynecologic malignancies. Therefore, there is a growing need for innovative therapies and techniques for monitoring and prevention of this disease. The exact cause of most ovarian tumors usually remains unknown. Ovarian cancer is believed to be caused by a range of different variables. This review is an attempt to summarize some genetic factors involved in the disruption of certain signaling pathways responsible for ovarian tumor transformation and development. Those factors considerably contribute to accurate diagnostics, treatment and prognosis in ovarian cancer.
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