Journal
FRONTIERS IN BIOSCIENCE-LANDMARK
Volume 17, Issue -, Pages 1499-1516Publisher
FRONTIERS IN BIOSCIENCE INC
DOI: 10.2741/4000
Keywords
B cell subpopulations; Marginal zone B cells; Transitional B cells; Follicular mature B cells; B-1 B cells; BAFF; TRL; MyD88; IRAK-4 deficient patients; MyD88 deficient patients; LPS; CpG; R848; Review
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Funding
- German Research Foundation (Deutsche Forschungsgemeinschaft) [ME2709/2-1]
- European Union [IRG 256372]
- NIH [HD037091, AI071163]
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B cells exhibit a range of functional responses following TLR engagement including immunoglobulin and cytokine production, proliferation, antigen presentation and migration. However, B cell intrinsic TLR responses appear to be precisely programmed based upon the developmental stage of the cell. B cell subpopulations classified as innate immune cells including marginal zone and B-1 B cells exhibit robust responses to TLR stimulation. In contrast, activation of other B cell subsets is constrained via a variety of developmentally regulated events. In this review we provide an overview of TLR responses in murine and human B cells and specifically highlight patterns of TLR expression and developmentally regulated functional responses.
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