Journal
FRONTIERS IN BIOSCIENCE-LANDMARK
Volume 17, Issue -, Pages 1715-1728Publisher
FRONTIERS IN BIOSCIENCE INC
DOI: 10.2741/4014
Keywords
Telomere; Shelterin; DSB; ssDNA; DNA damage response; Checkpoint; NHEJ; HR; Review
Categories
Funding
- Associazione Italiana per la Ricerca sul Cancro [IG5636]
- MIUR/Universita di Milano-Bicocca
- EU [PITN-GA-2008-215148]
- Fondazione Confalonieri
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The ends of eukaryotic chromosomes need to be protected from detection as DNA double strand breaks by the DNA damage response pathways. Failure to do so would have devastating consequences for genome integrity. Packaging of chromosome ends into protective structures called telomeres prevents checkpoint activation and DNA repair/recombination activities. Several studies on a variety of organisms have revealed that protein complexes with specificity for telomeric DNA protect chromosome ends from being recognized as DNA double-strand breaks and regulate telomere maintenance by the telomerase. In this review, we will discuss the consequences of telomere dysfunction and our understanding of how telomere integrity is maintained.
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