Journal
FRONTIERS IN BIOSCIENCE-LANDMARK
Volume 17, Issue -, Pages 1418-1432Publisher
FRONTIERS IN BIOSCIENCE INC
DOI: 10.2741/3995
Keywords
Natural Killer cells; Signal transduction; Mathematical Modeling; Systems Biology; Innate Immunity; Review
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Funding
- BMBF (BioFuture)
- DFG [WA1552/5-1, TRR83]
- Deutsche Krebshilfe
- Helmholtz Alliance on Systems Biology (SBCancer)
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Natural Killer (NK) cells are important for early immune reactions against viral infections and cancer. They are regulated by a highly redundant system of different activating and inhibitory receptors. Here we summarize our current understanding about the regulation of these cells and describe how mathematical modeling and systems biology approaches can help to shed some light on the complex regulatory network that governs NK cell reactivity.
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