Journal
FRONTIERS IN BIOSCIENCE-LANDMARK
Volume 16, Issue -, Pages 898-936Publisher
FRONTIERS IN BIOSCIENCE INC
DOI: 10.2741/3726
Keywords
Tight Junction; Barrier function; Cancer; Metastasis; Review
Categories
Funding
- Cancer Research Wales
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Tight Junctions (TJ) are well known to function as a control for the paracellular diffusion of ions and certain molecules, it has however, become evident that the TJ has a vital role in maintaining cell to cell integrity. Loss of cohesion of the TJ structure can lead to invasion and ultimately to the metastasis of cancer cells. This review will discuss how modulation of expression of TJ molecules results in key changes in TJ barrier function leading to the progression of cancer and progression of metastasis.
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