Journal
FRONTIERS IN BIOSCIENCE-LANDMARK
Volume 16, Issue -, Pages 1-12Publisher
FRONTIERS IN BIOSCIENCE INC
DOI: 10.2741/3671
Keywords
Insulin Resistance; Hypothalamo-Pituitary-Adrenal Pathway; Parasympathetic; Sympathetic; Neuropeptide Y; leptin; GLUT-4; Melanocortin; Brain Monoamines; Obese rat (fa/fa); Zucker rat; Insulin Receptor; Melanocortin; Norepinephrine; Dopamine; Review
Categories
Funding
- Department of Biotechnology, India
- CONICET
- Agencia Cordoba Ciencia
- SECYT-UNC (Argentina)
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There is reasonable evidence to suggest that insulin resistance may have its origins in the hypothalamus. Insulin secretion is regulated by sympathetic and parasympathetic nervous systems and modulates the concentrations of hypothalamic neuropeptides and monoaminergic neurotransmitters, and, in return, hypothalamic monoamines regulate the secretion of insulin by pancreatic beta cells. A lesion of the ventromedial hypothalamus produces all the features of the metabolic syndrome including insulin resistance and hyperinsulinemia. These and other evidence suggest that insulin resistance may very well be a disease of the brain.
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