Journal
FRONTIERS IN BIOSCIENCE-LANDMARK
Volume 15, Issue -, Pages 151-165Publisher
FRONTIERS IN BIOSCIENCE INC
DOI: 10.2741/3612
Keywords
Tumor microenvironment; growth factor; EGFR; FGF; PDGF; Review
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Funding
- NATIONAL CANCER INSTITUTE [R01CA131445] Funding Source: NIH RePORTER
- NCI NIH HHS [R01 CA131445] Funding Source: Medline
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Tumor microenvironment plays a critical role in tumor initiation and progression. Components in the microenvironment can modulate the growth of tumor cells, their ability to progress and metastasize. A major venue of communication between tumor cells and their microenvironment is through polypeptide growth factors and receptors for these growth factors. This article discusses three major classes of growth-stimulatory polypeptide growth factors and receptors for these growth factors. It also discusses how deregulation of these growth factors or their receptors can drive malignant transformation and progression.
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