Journal
FRONTIERS IN BIOSCIENCE-LANDMARK
Volume 14, Issue -, Pages 1490-1504Publisher
BIOSCIENCE RESEARCH INST-BRI
DOI: 10.2741/3320
Keywords
Gastric Cancer; African Enigma; Parasites; Prevention; Review
Categories
Funding
- Intramural NIH HHS [Z01 CP010150-08, Z01 CP010150] Funding Source: Medline
- NATIONAL CANCER INSTITUTE [ZIACP010150, ZIACP010176] Funding Source: NIH RePORTER
Ask authors/readers for more resources
Helicobacter pylori infection is ubiquitous, infecting close to one-half of the world's population, but its prevalence is declining in developed countries. Chronic H. pylori infection is etiologically linked to gastric adenocarcinoma, especially non-cardia type (63% of all stomach cancer or similar to 5.5% of the global cancer burden: similar to 25% of cancers associated with infectious etiology), and to gastric mucosal associated lymphoid tissue ( MALT) lymphoma, which accounts for up to 8% of all non-Hodgkin lymphoma. Epidemiological, clinical, and animal studies have established a central role for H. pylori in gastric carcinogenesis and provided insights into the mechanisms and biologic relationships between bacterial infection, host genetics, nutrition, and environmental factors. These discoveries invite strategies to prevent infection to be the logical primary goals in a multi-pronged effort to curtail suffering and death from H. pylori infection-associated cancers.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available