Journal
FRONTIERS IN BIOSCIENCE-LANDMARK
Volume 14, Issue -, Pages 2631-+Publisher
BIOSCIENCE RESEARCH INST-BRI
DOI: 10.2741/3401
Keywords
Apoptosis; Dendritic cells; Innate Immunity; Macrophages; Phagocytosis; Receptor Tyrosine Kinase; Tutorial; Review
Categories
Funding
- a Career Development Award and a Research Enhancement Award Program (REAP)
- Biomedical Laboratory Research AMP
- Development Service, Department of Veterans Affairs [RO1 HL056309, R01 HL082480, T32 HL07749]
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [T32HL007749, R01HL082480, R01HL056309] Funding Source: NIH RePORTER
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Mononuclear phagocytes comprise a mobile, broadly dispersed and highly adaptable system that lies at the very epicenter of host defense against pathogens and the interplay of the innate and adaptive arms of immunity. Understanding the molecular mechanisms that control the response of mononuclear phagocytes to apoptotic cells and the anti-inflammatory consequences of that response is an important goal with implications for multiple areas of biomedical sciences. This review details current understanding of the heterogeneity of apoptotic cell uptake by different members of the mononuclear phagocyte family in humans and mice. It also recounts the unique role of the Tyro3 family of receptor tyrosine kinases, best characterized for Mertk, in the signal transduction leading both to apoptotic cell ingestion and the anti-inflammatory effects that result.
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