Journal
FRONTIERS IN BIOSCIENCE
Volume 13, Issue -, Pages 4933-4937Publisher
FRONTIERS IN BIOSCIENCE INC
DOI: 10.2741/3052
Keywords
proteoglycans; versican; hyaluronan; atherosclerosis; smooth muscle cells; leukocytes; review
Categories
Funding
- PHS HHS [18645] Funding Source: Medline
Ask authors/readers for more resources
Hyaluronan and versican are extracellular matrix (ECM) macromolecules that are present in low amounts in normal blood vessels, but increase dramatically in vascular disease. These ECM components are particularly enriched in intimal hyperplasia as seen in human restenotic lesions following balloon angioplasty and provide a permissive environment for arterial smooth muscle cell (ASMC) proliferation, migration, and macrophage adhesion. Interference with the association of hyaluronan and versican with the surface of ASMCs, either through short oliogosaccharides of hyaluronan or blocking antibodies to the hyaluronan receptor, CD44, blocks the proliferative and migratory response of these cells to growth factors, such as platelet derived growth factor (PDGF). Agents that interfere with the proliferative response of ASMCs and that are used in the treatment of restenosis, such as rapamycin, inhibit the synthesis of hyaluronan by these cells. Inhibition of versican by versican antisense blocks proliferation of SMCs. The synthesis of hyaluronan and versican is highly regulated and influenced by proinflammatory growth factors such as PDGF and transforming growth factor-beta (TGF-beta).
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available