Journal
FRONTIERS IN BIOSCIENCE-LANDMARK
Volume 13, Issue -, Pages 5138-5154Publisher
FRONTIERS IN BIOSCIENCE INC
DOI: 10.2741/3070
Keywords
chemotherapy; drug resistance; molecular-targeted therapy; review
Categories
Funding
- Cancer Research UK Funding Source: Medline
- Medical Research Council [G0400302] Funding Source: Medline
- MRC [G0400302] Funding Source: UKRI
- Medical Research Council [G0400302] Funding Source: researchfish
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Resistance to chemotherapy ('drug resistance') is a fundamental problem that limits the effectiveness of many chemotherapies currently used to treat cancer. Drug resistance can occur due to a variety of mechanisms, such as increased drug inactivation, drug efflux from cancer cells, enhanced repair of chemotherapy-induced damage, activation of pro-survival pathways and inactivation of cell death pathways. In this article, we review some of the major mechanisms of drug resistance and discuss how new molecularly-targeted therapies are being increasingly used to overcome these resistance mechanisms.
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