Journal
FRONTIERS IN BIOSCIENCE-LANDMARK
Volume 13, Issue -, Pages 1711-1715Publisher
FRONTIERS IN BIOSCIENCE INC
DOI: 10.2741/2794
Keywords
microneedles arrays; vaccination; transdermal administration; needleshaped microstructures; dextrin microneedles; biodegradable hollow microneedles; injection; review
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The stratum corneum is the main barrier for transdermal drug transport. It could be bypassed by microneedles, which have a length of a few tens to a few hundreds of microns. They are usually arranged in arrays and can be used in several ways to enhance transdermal drug transport. Microneedles can be inserted into the skin in order to increase its permeability, after which the drug is applied (poak with patch). Drugs could also be coated onto the microneedles and be inserted into the skin (coat and poke). Hollow microneedles are used to inject drug solutions in to the skin. This review aims to discuss recently published in vivo and in vitro studies on microneedle aided transdermal drug delivery.
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