Journal
FRONTIERS IN BIOSCIENCE
Volume 13, Issue -, Pages 6126-6134Publisher
FRONTIERS IN BIOSCIENCE INC
DOI: 10.2741/3142
Keywords
SWI; SNF2; ISWI; SNF2H; chromatin remodeling; hereditary syndromes; tumors; leukemia; review
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Chromatin structure and its changes or maintenance throughout developmental checkpoints play indispensable role in organismal homeostasis. Chromatin remodeling factors of the SWI/SNF2 superfamily use ATP hydrolysis to change DNA-protein contacts, and their loss-of-function or inappropriate increase leads to distinct human pathologic states. In this review, we focus on the translational view of human pathologic physiology involving SWI/SNF2 superfamily, combining latest finding from basic and clinical research. We discuss in mechanistic terms the consequences resulting from dose alteration of the SWI/SNF2 superfamily ATPases and emphasize the necessity of future human subject-based studies.
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