Journal
FRONTIERS IN BIOSCIENCE-LANDMARK
Volume 13, Issue -, Pages 4198-4217Publisher
FRONTIERS IN BIOSCIENCE INC
DOI: 10.2741/3000
Keywords
endothelium-derived hyperpolarizing factor; EDHF; endothelium-derived contracting factor; EDCF; endothelin-1; ET; nitric oxide; Connexins; TRP channels; Na+-K+-ATPase; lipoxygenase; cytochrome P450 monoxygenases; heme oxygenase; carbon monoxide; C-type natriuretic peptide; hydrogen peroxide
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The endothelium can elicit relaxations and contractions of the underlying smooth muscle cells. It does so by releasing vasodilator (EDRF) and vasoconstrictor (EDCF) mediators. Among the diffusible endothelial factors nitric oxide (NO) plays a key role, particularly in large blood vessels. This chapter briefly reviews the interactions between NO and the other vasomotor signals released by the endothelial cells.
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