Journal
FRONTIERS IN BIOSCIENCE-LANDMARK
Volume 13, Issue -, Pages 2421-2434Publisher
FRONTIERS IN BIOSCIENCE INC
DOI: 10.2741/2855
Keywords
cellular cardiomyoplasty; cell delivery techniques; intramyocardial injection; intracoronary injection; retrograde coronary venous injection; systemic intravenous injection; cellular retention; washout; cellular engraftment; cell survival; enhancing cell retention and; survival; review
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Experimental and clinical studies have proven the feasibility of cellular cardiomyoplasty in treating the damaged myocardium following ischemic injury. Over the years, this field has exploded with different investigators trying different routes of cell delivery ranging from direct cell injection into the heart to peripheral intravenous delivery utilizing the various signaling mechanisms known. These different routes have resulted in a wide range of retention and engraftment of cells in the target tissues. In this review, we will explore the different modalities of cell delivery, the pros and cons of each route and the cellular retention and therapeutic efficacy of these routes. We will then look into the different theories that try to explain the observed retention and engraftment of cells in the target tissues. Finally, we will discuss various methods that can improve cellular retention and engraftment and hence better improvement in myocardial function.
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