Journal
FREE RADICAL RESEARCH
Volume 48, Issue 3, Pages 371-379Publisher
TAYLOR & FRANCIS LTD
DOI: 10.3109/10715762.2013.872779
Keywords
curcumin; oxidative stress; signaling pathway; C. elegans
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Funding
- NIH National Center for Research Resources
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Curcumin (diferuloylmethane),a pharmacologically active substance derived from turmeric, exhibits anti-infl ammatory, anticarcinogenic, and antioxidant properties. We examined the modulation of oxidative-stress resistance and associated regulatory mechanisms by curcumin in a Caenorhabditis elegans model. Our results showed that curcumin-treated wild-type C. elegans exhibited increased survival during juglone-induced oxidative stress compared with the control treatment. In addition, curcumin reduced the levels of intracellular reactive oxygen species in C. elegans. Moreover, curcumin induced the expression of the gst-4 and hsp-16.2 stress response genes. Lastly, our findings from the mechanistic study in this investigation suggest that the antioxidative effect of curcumin is mediated via regulation of age-1, akt-1, pdk-1, osr-1, unc-43, sek-1, skn-1, sir-2.1, and mev-1. Our study elucidates the diverse modes of action and signaling pathways that underlie the antioxidant activity exhibited by curcumin in vivo.
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