Journal
FREE RADICAL RESEARCH
Volume 46, Issue 10, Pages 1249-1257Publisher
TAYLOR & FRANCIS LTD
DOI: 10.3109/10715762.2012.702899
Keywords
catalase gene; catalase polymorphisms; diabetes mellitus; reactive oxygen species; hydrogen peroxide; decreased catalase
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Funding
- OTKA (Hungarian Scientific Research Fund) [T 71903]
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Oxidative stress and deficiency of the enzyme catalase, which is the primary scavenger of the oxidant H2O2, may contribute to diabetes. The current study examined two polymorphisms in the catalase gene, -262C > T in the promoter and 111C > T in exon 9, and their eff ects on blood catalase activity as well as on concentrations of blood glucose, haemoglobin A1c, triglyceride, cholesterol, HDL, LDL, ApoA-I and ApoB. Subjects were type-1 and type-2 diabetics. We evaluated PCR-single strand conformational polymorphism for 111C > T and PCR-restriction fragment length polymorphism for -262C > T. TT genotype frequency of 111C > T polymorphism was increased in type-1 diabetes. Type-2 diabetics with the CC or CT genotypes had decreased catalase and increased glucose, hemoglobinA1c and ApoB. Type-2 diabetics who have TT genotype in -262C > may have elevated risk for diabetes complications; these patients had the lowest mean catalase and HDL, as well as the highest glucose, haemoglobin A1c, cholesterol and ApoB.
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