Journal
FREE RADICAL RESEARCH
Volume 46, Issue 8, Pages 1019-1028Publisher
TAYLOR & FRANCIS LTD
DOI: 10.3109/10715762.2012.673720
Keywords
quercetin; quercetin-3-O-beta-D-glucuronide; Parkinson disease; 6-hydroxydopamine; oxidative stress
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Funding
- Ministry of Education, Culture, Sports, Science, and Technology
- Program for the Promotion of Basic and Applied Researches for Innovations in Bio-oriented Industry in Japan
- Grants-in-Aid for Scientific Research [23780136, 23658119, 23658118] Funding Source: KAKEN
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Quercetin is ubiquitously distributed in plant foods. This antioxidative polyphenol is mostly converted to conjugated metabolites in the body. Parkinson disease (PD) has been suggested to be related to oxidative stress derived from abnormal dopaminergic activity. We evaluated if dietary quercetin contributes to the antioxidant network in the central nervous system from the viewpoint of PD prevention. A neurotoxin, 6-hydroxydopamine (6-OHDA), was used as a model of PD. 6-OHDA-induced H2O2 production and cell death in mouse neuroblastoma, Neuro-2a. Quercetin aglycone suppressed 6-OHDA-induced H2O2 production and cell death, although aglycone itself reduced cell viability at higher concentration. Quercetin 3-O-beta-D-glucuronide (Q3GA), which is an antioxidative metabolite of dietary quercetin, was little incorporated into the cell resulting in neither suppression of 6-OHDA-induced cell death nor reduction of cell viability. Q3GA was found to be deconjugated to quercetin by microglial MG-6 cells. These results indicate that quercetin metabolites should be converted to their aglycone to exert preventive effect on damage to neuronal cells.
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