Journal
FREE RADICAL RESEARCH
Volume 46, Issue 10, Pages 1183-1189Publisher
TAYLOR & FRANCIS LTD
DOI: 10.3109/10715762.2012.698009
Keywords
antioxidants; molecular damage; metabolism; rate of living; fish; growth; transgenic; GH
Categories
Funding
- Swedish Council for Forestry and Agricultural Research
- Canadian Regulatory System for Biotechnology
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Growth hormone (GH) transgenic fish have dramatically enhanced growth rates, increased oxygen demands and reactive oxygen species production. GH-transgenic coho salmon provide an opportunity to address effects of increased metabolism on physiological aging. The objective of this study was to compare oxidative stress in wild-type (WT) and GH-transgenic (T) coho salmon (Oncorhynchus kisutch) of different ages (1 and 2 years). Antioxidant enzyme activity, protein carbonyls (PC) and glutathione (GSH, GSSG) were measured. PC correlated to growth rates in individual fish. T fish exhibited lower antioxidant enzyme activities and GSH levels compared to the WT, while levels of PC and GSSG were higher. Age affects were observed in both WT and T fish; enzyme activities and GSH decreased while PC and GSSG increased. Our results support the metabolic rate theory of aging. This study aims to be a platform for continued studies of the theories of aging using fish as model organisms.
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