Journal
FREE RADICAL RESEARCH
Volume 44, Issue 10, Pages 1098-1124Publisher
TAYLOR & FRANCIS LTD
DOI: 10.3109/10715762.2010.498477
Keywords
Lipid peroxidation; alkenals; 4-hydroxy-2-nonenal; glutathione; apoptosis; adducts; volatile aldehydes
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Oxidative stress and resulting lipid peroxidation is involved in various and numerous pathological states including inflammation, atherosclerosis, neurodegenerative diseases and cancer. This review is focused on recent advances concerning the formation, metabolism and reactivity towards macromolecules of lipid peroxidation breakdown products, some of which being considered as 'second messengers' of oxidative stress. This review relates also new advances regarding apoptosis induction, survival/proliferation processes and autophagy regulated by 4-hydroxynonenal, a major product of omega-6 fatty acid peroxidation, in relationship with detoxication mechanisms. The use of these lipid peroxidation products as oxidative stress/lipid peroxidation biomarkers is also addressed.
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