Journal
FREE RADICAL RESEARCH
Volume 44, Issue 7, Pages 721-733Publisher
TAYLOR & FRANCIS LTD
DOI: 10.3109/10715762.2010.485989
Keywords
Chromatin; histones; genetic instability; cell cycle; glutathione
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Cells with high proliferation rate have high glutathione levels. This typical feature of cancer cells is viewed usually as a defence mechanism against ionizing radiation or chemotherapy. Efforts have been made in order to decrease cellular glutathione levels in tumours as a necessary pre-treatment for cancer therapy. However, very few reports have considered cellular glutathione as a physiological tool for cells to proliferate and that most of this high glutathione levels were located in the nucleus. The role of nuclear glutathione in cell physiology has become more important in the last years. This review summarizes new findings that point to the nuclear reduced status as an environment that induces heterochromatin formation. Glutathionylation and oxidation of nuclear proteins appear as a reversible physiological mechanism able to regulate DNA compaction, cell cycle and DNA repair.
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